{{Rsnum
|rsid=6835457
|Chromosome=4
|position=122589971
|Orientation=plus
|GMAF=0.3719
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 41.5 | 50.8 | 7.7
| HCB | 15.9 | 47.7 | 36.4
| JPT | 17.8 | 55.6 | 26.7
| YRI | 41.3 | 50.8 | 7.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 15.9 | 47.7 | 36.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs6835457]] is a SNP in the 3'-UTR flanking region of the [[IL21]] gene.

A study including both European (4,248 patients) and African-Americans (1,569 patients) with [[lupus]] focusing on the [[IL2]]/[[IL21]] gene region on chromosome 4q27 concluded that 2 tightly linked SNPs were associated with increased risk for the disease, [[rs907715]] and [[rs6835457]], with odds ratios of 1.16 (CI: 1.1-1.22, p=2x10e-8) and 1.11 (CI:1.05-1.17, p=9x10e-5), respectively.{{PMID|21425124|OA=1
}}
{{PMID Auto
|PMID=23172754
|Title=Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility
}}