{{Rsnum
|rsid=6859
|Gene=PVRL2
|Chromosome=19
|position=44878777
|Orientation=plus
|GMAF=0.3898
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PVRL2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 19.5 | 49.6 | 31.0
| HCB | 12.4 | 41.6 | 46.0
| JPT | 11.5 | 49.6 | 38.9
| YRI | 23.1 | 51.7 | 25.2
| ASW | 21.1 | 47.4 | 31.6
| CHB | 12.4 | 41.6 | 46.0
| CHD | 6.4 | 49.5 | 44.0
| GIH | 8.9 | 40.6 | 50.5
| LWK | 14.5 | 57.3 | 28.2
| MEX | 5.2 | 50.0 | 44.8
| MKK | 17.3 | 39.7 | 42.9
| TSI | 18.6 | 52.0 | 29.4
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18823527
|Trait=Alzheimer's disease
|Title=A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
|RiskAllele=A
|Pval=5.9999999999999997E-14
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs6859
|Name_s=
|Gene_s=PVRL2
|Feature=
|Evidence=PubMed ID:18823527; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. (Initial Sample Size: 1,082 cases, 1,239 controls; Replication Sample Size: 1,400 additional controls); (Region: 19q13.32; Reported Gene(s): PVRL2, TOMM40, APOE; Risk Allele: rs6859-A); (p-value= 5.99999999999999E-14).This variant is associated with Alzheimer's disease.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740849
}}

The risk allele associated with late-onset [[Alzheimer's disease]] is A. {{PMID|18823527|OA=1
}}
{{PMID Auto GWAS
|PMID=20885792
|Trait=None
|Title=Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities
|RiskAllele=A
|Pval=1E-7
|OR=1.41
|ORtxt=[1.24-1.60]
|OA=1
}}

{{PMID Auto GWAS
|PMID=22159054
|Trait=None
|Title=A comprehensive genetic association study of Alzheimer disease in African Americans.
|RiskAllele=A
|Pval=5E-7
|OR=1.5800
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19265542
|Title=Performance of random forest when SNPs are in linkage disequilibrium.
|OA=1
}}

{{PMID Auto
|PMID=19734902
|Title=Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=21390209
|Title=Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6859
|overall_frequency_n=65
|overall_frequency_d=126
|overall_frequency=0.515873
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23193196
|Title=Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}