{{Rsnum
|rsid=686
|Gene=DRD1
|Chromosome=5
|position=175441697
|Orientation=plus
|GMAF=0.382
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DRD1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 26.5 | 61.9 | 11.5
| HCB | 70.6 | 27.2 | 2.2
| JPT | 78.8 | 18.6 | 2.7
| YRI | 13.7 | 48.6 | 37.7
| ASW | 30.4 | 37.5 | 32.1
| CHB | 70.6 | 27.2 | 2.2
| CHD | 73.4 | 24.8 | 1.8
| GIH | 39.6 | 43.6 | 16.8
| LWK | 12.8 | 41.3 | 45.9
| MEX | 43.9 | 49.1 | 7.0
| MKK | 30.8 | 50.0 | 19.2
| TSI | 33.3 | 52.0 | 14.7
| HapMapRevision=28
}}

Implicated as part of a haplotype of the dopamine D1 receptor [[DRD1]] gene associated with [[autism]] spectrum disorders in families having only affected males. The haplotype is [[rs265981]](C)-[[rs4532]](A)-[[rs686]](T) as published, though not necessarily as oriented in dbSNP.{{PMID|18205172}}

{{omim
|desc=TOBACCO ADDICTION, SUSCEPTIBILITY TO
|id=188890
|rsnum=686
}}

{{omim
|desc=DOPAMINE RECEPTOR D1; DRD1
|id=126449
|rsnum=686
}}

{{PMID Auto
|PMID=20456319
|Title=Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia
}}

{{PMID|18092181}} Significant association of DRD1 with nicotine dependence.

{{PMID|18341651}} A haplotype of the DRD1 gene is associated with alcohol dependence.

{{PMID|18937842|OA=1
}} The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.

{{PMID|19135651|OA=1
}} Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504.

{{PMID|19500151|OA=1
}} Heroin addiction in African Americans: a hypothesis-driven association study.

{{PMID|21332319}} Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response.

{{PMID|21955727}} An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia.

{{PMID|22574669}} Dopamine receptors D1 and D2 are related to observed maternal behavior.

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}