{{Rsnum
|rsid=688034
|Gene=SEZ6L
|Chromosome=22
|position=26293669
|Orientation=plus
|GMAF=0.1602
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SEZ6L
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 45.1 | 43.4 | 11.5
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 90.5 | 9.5 | 0.0
| ASW | 75.4 | 21.1 | 3.5
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 86.1 | 12.9 | 1.0
| LWK | 86.4 | 13.6 | 0.0
| MEX | 65.5 | 31.0 | 3.4
| MKK | 76.3 | 22.4 | 1.3
| TSI | 46.1 | 44.1 | 9.8
| HapMapRevision=28
}}
[[rs688034]] has been reported in a large study to be associated with [[heart disease]], in particular, [[coronary artery disease]].

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.11 (CI 0.98-1.25), and for homozygotes, 1.62 (CI 1.34-1.95). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs688034
|PubMedID=17554300
|Condition=Coronary disease
|Gene=NR
|Risk Allele=T
|pValue=4.00E-006
|OR=1.11
|95CI=0.99-1.25
|OA=1
}}

{{PharmGKB
|RSID=rs688034
|Name_s=
|Gene_s=SEZ6L
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,926 cases, 2,938 controls; Replication Sample Size: (see Samani 2007); Risk Allele: rs688034-T). This variant is associated with coronary disease.
|Drugs=
|Drug Classes=
|Diseases=Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356656
}}

{{PMID Auto
|PMID=19956433
|Title=Genetics of coronary artery disease: focus on genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20017983
|Title=Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs688034
|overall_frequency_n=18
|overall_frequency_d=128
|overall_frequency=0.140625
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}