{{Rsnum
|rsid=6885099
|Gene=PDE8B
|Chromosome=5
|position=77234524
|Orientation=plus
|GMAF=0.3655
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PDE8B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 31.0 | 51.3 | 17.7
| HCB | 1.5 | 27.0 | 71.5
| JPT | 4.4 | 21.2 | 74.3
| YRI | 4.8 | 28.6 | 66.7
| ASW | 5.3 | 47.4 | 47.4
| CHB | 1.5 | 27.0 | 71.5
| CHD | 0.9 | 25.7 | 73.4
| GIH | 19.8 | 57.4 | 22.8
| LWK | 3.7 | 24.8 | 71.6
| MEX | 15.5 | 51.7 | 32.8
| MKK | 2.6 | 32.1 | 65.4
| TSI | 40.2 | 47.1 | 12.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs6885099
|Name_s=
|Gene_s=PDE8B
|Feature=
|Evidence=PubMed ID:18514160
|Annotation=In a GWAS, this SNP showed strong association with levels of circulating Thyroid-stimulating hormone (TSH). The initial GWAS was done on 4300 Sardinians and the association was replicated in additional Sardinians plus Tuscan and Old Order Amish cohorts (4158 individuals).
|Drugs=
|Drug Classes=
|Diseases=Thyroid Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA161748312
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6885099
|overall_frequency_n=90
|overall_frequency_d=128
|overall_frequency=0.703125
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23408906
  |Trait=Thyroid hormone levels
  |Title=A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
  |RiskAllele=A
  |Pval=2E-26
  |OR=.14
  |ORtxt=[0.12-0.16] unit decrease
  |OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}