{{Rsnum
|rsid=6887695
|Chromosome=5
|position=159395637
|Orientation=plus
|GMAF=0.3976
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 8.9 | 47.3 | 43.8
| HCB | 14.1 | 50.4 | 35.6
| JPT | 23.0 | 39.8 | 37.2
| YRI | 24.0 | 51.4 | 24.7
| ASW | 19.6 | 39.3 | 41.1
| CHB | 14.1 | 50.4 | 35.6
| CHD | 18.9 | 51.9 | 29.2
| GIH | 16.0 | 47.0 | 37.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 19.0 | 34.5 | 46.6
| MKK | 24.4 | 50.6 | 25.0
| TSI | 14.0 | 50.0 | 36.0
| HapMapRevision=28
}}IL12B gene SNP, part of a haplotype with [[rs3212227]] associated with [[psoriasis]].{{PMID|18219280|OA=1
}}

{{PMID|18369459|OA=1
}} [[rs6887695]] confirmed to be associated with [[psoriasis]] in another study

A study of 500+ patients with [[psoriatic arthritis]] (PsA) concluded that the odds ratio for [[rs6887695]](G;G) carriers was 1.43 (CI: 1.18-1.74). The effect sizes observed in patients with PsA appear to be smaller than those previously reported in patients with psoriasis, suggesting that both loci are primarily associated with [[psoriasis]] susceptibility rather than primarily with [[psoriatic arthritis]].{{PMID|19035472|OA=1
}}

{{PMID Auto GWAS
|PMID=17554261
|Trait=Crohn's disease
|Title=Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
|RiskAllele=
|Pval=0.0000090000000000000002
|OR=1.26
|ORtxt=[1.12-1.41]
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 19; IBD19
|id=612278
|rsnum=6887695
}}

{{PMID Auto
|PMID=19705136
|Title=Genetic evidence for involvement of the IL23 pathway in Thai psoriatics
|OA=1
}}

{{PMID Auto
|PMID=19953089
|Title=Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
}}

{{omim
|id=605606
|rsnum=6887695
}}

{{omim
|id=607507
|rsnum=6887695
}}

{{omim
|id=612599
|rsnum=6887695
}}

{{PMID Auto
|PMID=22621617
|Title=No Association between IL12B Gene Polymorphisms and Graves' Disease in the Chinese Population
}}

{{PMID Auto
|PMID=22666261
|Title=The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population
|OA=1
}}

{{PMID Auto
|PMID=22739501
|Title=Resequencing of the IL12B gene in psoriasis patients with the rs6887695/rs3212227 risk genotypes
}}

{{PMID Auto
|PMID=17236132
|Title=A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
|OA=1
}}

{{PMID Auto
|PMID=18383521
|Title=IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interaction.
}}

{{PMID Auto
|PMID=18438406
|Title=Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=18533027
|Title=Worldwide population differentiation at disease-associated SNPs.
|OA=1
}}

{{PMID Auto
|PMID=18609743
|Title=Genetics of psoriasis and psoriatic arthritis: update and future direction.
|OA=1
}}

{{PMID Auto
|PMID=18800148
|Title=Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.
}}

{{PMID Auto
|PMID=18936107
|Title=Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.
}}

{{PMID Auto
|PMID=19140132
|Title=Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
|OA=1
}}

{{PMID Auto
|PMID=19182814
|Title=New insights into the pathogenesis and genetics of psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19838195
|Title=A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=20606885
|Title=Genetics of psoriasis and psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20875477
|Title=Replication of association between interleukin-23 receptor (IL-23R) and its ligand (IL-12B) polymorphisms and psoriasis in the Chinese Han population.
}}

{{PMID Auto
|PMID=21198744
|Title=The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype.
}}

{{PMID Auto
|PMID=21214922
|Title=Psoriasis prediction from genome-wide SNP profiles.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6887695
|overall_frequency_n=52
|overall_frequency_d=128
|overall_frequency=0.40625
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23093722
|Title=Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis
}}

{{PMID Auto
|PMID=22194214
|Title=Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
}}

{{PMID Auto
|PMID=23578145
|Title=Levels of interleukin-(IL)-12p40 are markedly increased in brucellosis among patients with specific IL-12B genotypes
}}

{{PMID Auto
|PMID=24140476
|Title=Genetic variations in IL6 and IL12B decreasing the risk for psoriasis
}}

{{PMID Auto
|PMID=23297015
|Title=Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis
}}

{{PMID Auto
|PMID=23564024
|Title=Association of IL-12B gene rs6887695 polymorphism with hereditary susceptibility and clinical characterization of psoriasis vulgaris in the Chinese Han population.
}}

{{PMID Auto
|PMID=24957500
|Title=Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}