{{Rsnum
|rsid=689
|Gene=INS
|Chromosome=11
|position=2160994
|Orientation=minus
|GMAF=0.3352
|Gene_s=INS,INS-IGF2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}A strong association between [[rs689]], a SNP within the insulin [[INS]] gene, has been reported with [[type-1 diabetes]] {{PMID|15220214}}

Several studies (including {{PMID|17554300|OA=1
}}) have mentioned replicating this result, although without mentioning specific risk odds.

{{PMID Auto
|PMID=19956106
|Title=Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families
|OA=1
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=
|Pval=0
|OR=None
|ORtxt=[2.04-2.63]
|OA=1
}}

{{PMID|16595598}} The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.

{{PMID|17334650|OA=1
}} A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.

{{PMID|17554260|OA=1
}} Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

{{PMID|17606874|OA=1
}} Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.

{{PMID|17667841}} Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels.

{{PMID|17683561|OA=1
}} The TCF7L2 locus and type 1 diabetes.

{{PMID|17700581}} Association between small for gestational age and paternally inherited 5' insulin haplotypes.

{{PMID|18085551}} Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease.

{{PMID|18252225|OA=1
}} On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

{{PMID|18292987|OA=1
}} Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.

{{PMID|18310307}} Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.

{{PMID|18375961|OA=1
}} Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.

{{PMID|18556337|OA=1
}} Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

{{PMID|18940880}} Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese.

{{PMID|19020323|OA=1
}} Genotype score in addition to common risk factors for prediction of type 2 diabetes.

{{PMID|19073967|OA=1
}} Shared and distinct genetic variants in type 1 diabetes and celiac disease.

{{PMID|19168599|OA=1
}} Type 1 diabetes in the BB rat: a polygenic disease.

{{PMID|19188433|OA=1
}} Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

{{PMID|19434426|OA=1
}} Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth.

{{PMID|19956109|OA=1
}} The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

{{PMID|20144318|OA=1
}} A strategy for analyzing gene-nutrient interactions in type 2 diabetes.

{{PMID|20628762|OA=1
}} Allele-specific recognition of the 3' splice site of INS intron 1.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{PMID|22511809}} Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.

{{PMID Auto
|PMID=23721563
|Title=Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes: INS and IKZF4 associate with insulin autoantibodies
}}

{{PMID Auto
|PMID=24275212
|Title=The role of tyrosine hydroxylase gene variants in suicide attempt in schizophrenia
}}

{{PMID Auto
|PMID=23835325
|Title=Patterns of beta-cell autoantibody appearance and genetic associations during the first years of life.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}