{{Rsnum
|rsid=689466
|Gene=PTGS2
|Chromosome=1
|position=186681619
|Orientation=minus
|GMAF=0.2534
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PTGS2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 71.7 | 23.0 | 5.3
| HCB | 28.5 | 49.6 | 21.9
| JPT | 34.5 | 41.6 | 23.9
| YRI | 83.7 | 16.3 | 0.0
| ASW | 80.7 | 19.3 | 0.0
| CHB | 28.5 | 49.6 | 21.9
| CHD | 31.2 | 42.2 | 26.6
| GIH | 75.2 | 22.8 | 2.0
| LWK | 92.7 | 6.4 | 0.9
| MEX | 58.6 | 37.9 | 3.4
| MKK | 93.6 | 6.4 | 0.0
| TSI | 66.7 | 31.4 | 2.0
| HapMapRevision=28
}}

[[rs689466]] is a SNP in the COX-2 gene, also known as the prostaglandin-endoperoxide synthase 2 [[PTGS2]] gene.

A Scottish and Danish case-control study including 732 Crohn's disease (CD) cases, 973 ulcerative colitis (UC) cases, and 1157 healthy controls found that the [[rs689466]](G) allele was associated with higher risk for [[ulcerative colitis]] and 
[[inflammatory bowel disease]], especially among those who never smoked. The reported odds ratios were 1.25 and 1.47, rspectively. This allele was also associated with younger age at diagnosis and with extensive ulcerative colitis.{{PMID|20803508}}

{{PMID Auto
|PMID=19748095
|Title=Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome
}}

{{PMID Auto
|PMID=20177132
|Title=COX-2 is Associated with Periodontitis in Europeans
}}

{{PMID Auto
|PMID=20431935
|Title=Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk
|OA=1
}}

{{PharmGKB
|RSID=rs689466
|Name_s=COX-2:(-1195)G>A, -1195G>A
|Gene_s=PTGS2
|Feature=
|Evidence=PubMed ID:16083713
|Annotation=Risk or phenotype-associated allele: A. Phenotype: The AA genotype was associated with increased risk for esophageal neoplasms. Functional analysis also showed increased transcription of promotor constructs with the A variant and binding of the cMYB transcription factor to constructs with the A variant but not the G variant. Study size:1026 cases; 1270 controls. Study population/ethnicity: Patients with esophageal squamous cell carcinoma; Chinese. Significance metric(s): OR = 1.72 (95% CI, 1.35-2.20). Type of association: FA; CO.
|Drugs=
|Drug Classes=
|Diseases=Esophageal Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165349774
}}

{{PharmGKB
|RSID=rs689466
|Name_s=PTGS2:(-1195)G>A, COX-2 -1195G>A
|Gene_s=PTGS2
|Feature=
|Evidence=PubMed ID:18489027
|Annotation=Risk or phenotype-associated allele: A. Phenotype: The A allele of the -1195 SNP was present at a significantly higher frequency among all asthmatic subjects compared to controls. Study size: 1234. Study population/ethnicity: Australian Caucasian population with asthma, aspirin-intolerant asthma and non-asthmatic controls. Significance metric(s): p = 0.012 Type of association: CO.
|Drugs=
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA165291705
}}
{{PMID Auto
|PMID=21124790
|Title=The Functional -765G?C Polymorphism of the COX-2 Gene May Reduce the Risk of Developing Crohn's Disease
|OA=1
}}

{{PMID Auto
|PMID=21283657
|Title=Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes
|OA=1
}}

{{PMID|17171651}} Cyclooxygenase-2 polymorphisms in Parkinson's disease.

{{PMID|18085997}} Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

{{PMID|18768181|OA=1
}} Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

{{PMID|19223558|OA=1
}} Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.

{{PMID|19318492|OA=1
}} Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.

{{PMID|19437564|OA=1
}} No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.

{{PMID|19930591|OA=1
}} Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.

{{PMID|21042835}} Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma.

{{PMID|21168919}} No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression.

{{PMID|21304218}} Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.

{{PMID|21538574}} Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.

{{PMID|21649724}} Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi-ethnic country.

{{PMID|21848701}} Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population.

{{PMID|21926110|OA=1
}} Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.

{{PMID|22037828}} Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs689466
|overall_frequency_n=22
|overall_frequency_d=128
|overall_frequency=0.171875
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=2
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23620771
|Title=The Association between COX-2 Polymorphisms and Hematologic Toxicity in Patients with Advanced Non-Small-Cell Lung Cancer Treated with Platinum-Based Chemotherapy
|OA=1
}}

{{PMID Auto
|PMID=23907768
|Title=Cyclooxygenase-2 Genetic Polymorphism and Stroke Subtypes in Chinese
}}

{{PMID Auto
|PMID=24194923
|Title=Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
|OA=1
}}

{{PMID Auto
|PMID=23029430
|Title=Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
|OA=1
}}

{{PMID Auto
|PMID=23777936
|Title=Influence of Cyclooxygenase-2 (COX-2) gene promoter-1195 and allograft inflammatory factor-1 (AIF-1) polymorphisms on allograft outcome in Hispanic kidney transplant recipients.
}}

{{PMID Auto
|PMID=23852948
|Title=Cyclooxygenase 2 genetic polymorphism may increase the risk of developing leukoaraiosis in Chinese.
}}

{{PMID Auto
|PMID=24789723
|Title=Cyclooxygenase-2 Polymorphisms and Breast Cancer Associated Risk in Pakistani Patients
}}

{{PMID Auto
|PMID=25166592
|Title=Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis
}}

{{PMID Auto
|PMID=25214704
|Title=Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}
{{on chip | NatGeo2}}