{{Rsnum
|rsid=6908425
|Gene=CDKAL1
|Chromosome=6
|position=20728500
|Orientation=plus
|GMAF=0.2172
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CDKAL1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 65.5 | 33.6 | 0.9
| HCB | 65.0 | 32.8 | 2.2
| JPT | 60.2 | 32.7 | 7.1
| YRI | 60.5 | 33.3 | 6.1
| ASW | 63.2 | 31.6 | 5.3
| CHB | 65.0 | 32.8 | 2.2
| CHD | 67.0 | 31.2 | 1.8
| GIH | 49.0 | 45.0 | 6.0
| LWK | 47.3 | 46.4 | 6.4
| MEX | 59.6 | 33.3 | 7.0
| MKK | 76.3 | 22.4 | 1.3
| TSI | 60.4 | 33.7 | 5.9
| HapMapRevision=28
}}[[rs6908425]] has been reported in a large study to be associated with [[Crohn's disease]].

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.63 (CI 1.38-2.25), and for homozygotes, 1.95 (CI 1.43-2.67). {{PMID|17554300|OA=1
}}

{{PMID Auto
|PMID=18923449
|Title=Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
}}

{{PMID Auto GWAS
|PMID=18587394
|Trait=Crohn's disease
|Title=Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease
|RiskAllele=C
|Pval=8.9999999999999999E-10
|OR=1.21
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=19587699
|Title=Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes
}}

{{omim
|id=177900
|rsnum=6908425
}}

{{PMID Auto
|PMID=19068216
|Title=Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
|OA=1
}}

{{PMID Auto
|PMID=19422935
|Title=Genetic risk profiling and prediction of disease course in Crohn's disease patients.
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19638187
|Title=Genetic susceptibility to psoriasis: an emerging picture.
|OA=1
}}

{{PMID Auto
|PMID=19915572
|Title=Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|OA=1
}}

{{PMID Auto
|PMID=20518082
|Title=Role of genetics in prediction of disease course and response to therapy.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6908425
|overall_frequency_n=105
|overall_frequency_d=128
|overall_frequency=0.820312
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=89
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=21102463
  |Trait=Crohn's disease
  |Title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
  |RiskAllele=C
  |Pval=1E-8
  |OR=1.17
  |ORtxt=[1.11-1.23]
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}