{{Rsnum
|rsid=6918698
|Gene=CTGF
|Chromosome=6
|position=131952117
|Orientation=plus
|GMAF=0.4986
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=CTGF
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 21.0 | 43.5 | 35.5
| HCB | 20.5 | 54.5 | 25.0
| JPT | 23.3 | 53.5 | 23.3
| YRI | 22.6 | 58.1 | 19.4
| ASW | 0.0 | 0.0 | 0.0
| CHB | 20.5 | 54.5 | 25.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs6918698]], a common SNP located in the promoter of the [[CTGF]] gene, has been linked to increased risk for [[systemic sclerosis]] (scleroderma) based on a study of 500 Caucasian patients. The odds ratio is 2.2 for (G;G) homozygotes (p<0.001). The reason that the (C) allele appears to be protective is thought to be due to decreased [[CTGF]] activity.{{PMID|17881752}}

{{omim
|desc=CONNECTIVE TISSUE GROWTH FACTOR; CTGF
|id=121009
|rsnum=6918698
}}
{{PMID Auto
|PMID=19243500
|Title=Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis
}}

{{PMID Auto
|PMID=22533709
|Title=The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=19054818
|Title=Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population.
}}

{{PMID Auto
|PMID=19822645
|Title=Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes.
|OA=1
}}

{{PMID Auto
|PMID=22503846
|Title=Connective tissue growth factor (CTGF/CCN2): A protagonist in cardiac allograft vasculopathy development?
}}

{{PMID Auto
|PMID=22554650
|Title=Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
|OA=1
}}

{{PMID Auto
|PMID=24121259
|Title=The Influence of CTGF Single-Nucleotide Polymorphisms on Outcomes in Crohn's Disease
}}

{{PMID Auto
|PMID=25030555
|Title=Association between Gene Polymorphisms of Connective Tissue Growth Factor and the Progression of Chronic Liver Disease Associated with Hepatitis C
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}