{{Rsnum
|rsid=6920220
|Chromosome=6
|position=137685367
|Orientation=plus
|GMAF=0.1047
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=rheumatoid arthritis
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 27.7 | 69.6
| HCB | 0.0 | 0.7 | 99.3
| JPT | 0.0 | 0.9 | 99.1
| YRI | 0.7 | 21.1 | 78.2
| ASW | 3.5 | 24.6 | 71.9
| CHB | 0.0 | 0.7 | 99.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 18.0 | 82.0
| LWK | 0.0 | 16.4 | 83.6
| MEX | 1.7 | 15.5 | 82.8
| MKK | 1.3 | 25.0 | 73.7
| TSI | 0.0 | 29.7 | 70.3
| HapMapRevision=28
}}

{{CPMC SNP
|link=https://cpmc.coriell.org/Sections/Genes/RheumatoidArthritis.aspx?PgId=219
}}
[[rs6920220]] has been reported in a large study to be associated with [[rheumatoid arthritis]].

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.20 (CI 1.06-1.36), and for homozygotes, 1.72 (CI 1.33-2.22). {{PMID|17554300|OA=1
}}

{{PMID|19417005|OA=1
}} [[rheumatoid arthritis]]
*[[rs6920220]] [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)]. 
*[[rs5029937]]
*[[rs13207033]] protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with [[rs10499194]]
The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)

{{PMID Auto
|PMID=19401279
|Title=Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
}}
{{PMID Auto GWAS
|PMID=18794853
|Trait=Rheumatoid arthritis
|Title=Common variants at CD40 and other loci confer risk of rheumatoid arthritis
|RiskAllele=
|Pval=2E-9
|OR=1.24
|ORtxt=[1.16-1.32]
|OA=1
}}
{{PMID Auto GWAS
|PMID=17982456
|Trait=Rheumatoid arthritis
|Title=Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
|RiskAllele=
|Pval=9.9999999999999995E-8
|OR=1.22
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=19565500
|Title=Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
|OA=1
}}

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 13; SLEB13
|id=612378
|rsnum=6920220
}}

{{omim
|desc=RHEUMATOID ARTHRITIS; RA
|id=180300
|rsnum=6920220
}}

{{PharmGKB
|RSID=rs6920220
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17982455; PubMed ID:17982456
|Annotation=This SNP has been associated with risk of rheumatoid arthritis by replicated GWAS.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA161613785
}}

{{PMID Auto
|PMID=20511617
|Title=Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population
}}
{{PMID Auto
|PMID=19366996
|Title=Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis
|OA=1
}}
{{PMID Auto GWAS
|PMID=20453842
|Trait=Rheumatoid arthritis
|Title=Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock
|RiskAllele=A
|Pval=9E-13
|OR=1.22
|ORtxt=[1.16-1.29]
}}
{{PMID Auto
|PMID=20921970
|Title=A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register
}}
{{PMID Auto
|PMID=21120996
|Title=Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans
|OA=1
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=A
|Pval=8E-17
|OR=1.1400
|ORtxt=[1.09-1.20]
|OA=1
}}

{{PMID|18625055|OA=1
}} Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

{{PMID|18794857|OA=1
}} Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

{{PMID|18853133|OA=1
}} Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

{{PMID|18987647|OA=1
}} Rheumatoid arthritis: a view of the current genetic landscape.

{{PMID|19165918|OA=1
}} Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

{{PMID|19169254|OA=1
}} Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

{{PMID|19180477|OA=1
}} Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.

{{PMID|19292917|OA=1
}} Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility.

{{PMID|19321514}} 6q23 polymorphisms in rheumatoid arthritis Spanish patients.

{{PMID|19387456|OA=1
}} Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.

{{PMID|19439038|OA=1
}} Complex genetic association of 6q23 with autoimmune rheumatic conditions.

{{PMID|19445664|OA=1
}} Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls.

{{PMID|19674979|OA=1
}} Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

{{PMID|19838195|OA=1
}} A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

{{PMID|19956648|OA=1
}} Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

{{PMID|20017963|OA=1
}} Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.

{{PMID|20018027|OA=1
}} Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.

{{PMID|20231195}} Lack of association between the rs6920220 (G/A) polymorphism of the 6q23 region and biopsy-proven giant cell arteritis.

{{PMID|20353580|OA=1
}} Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.

{{PMID|20426808|OA=1
}} AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.

{{PMID|20439292}} Genetic variants in the prediction of rheumatoid arthritis.

{{PMID|20444755|OA=1
}} Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

{{PMID|20617138|OA=1
}} Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population.

{{PMID|20973039}} Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.

{{PMID|21383967|OA=1
}} Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

{{PMID|21833526}} A Tunisian case-control association study of a 6q polymorphism in rheumatoid arthritis.

{{PMID|22402800}} Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6920220
|overall_frequency_n=15
|overall_frequency_d=128
|overall_frequency=0.117188
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Inflammatory bowel disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=A
  |Pval=1E-21
  |OR=1.10
  |ORtxt=[1.064-1.141]
  |OA=1
}}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
|OA=1
}}

{{PMID Auto
|PMID=22798268
|Title=Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA.
}}

{{PMID Auto
|PMID=22843550
|Title=Genetic variation and alterations of genes involved in NFkappaB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}