{{Rsnum
|rsid=6929137
|Gene=C6orf97
|Chromosome=6
|position=151615542
|Orientation=plus
|GMAF=0.3402
|Gene_s=CCDC170
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 5.3 | 41.6 | 53.1
| HCB | 11.8 | 43.4 | 44.9
| JPT | 8.0 | 40.2 | 51.8
| YRI | 21.9 | 51.4 | 26.7
| ASW | 15.8 | 56.1 | 28.1
| CHB | 11.8 | 43.4 | 44.9
| CHD | 11.1 | 43.5 | 45.4
| GIH | 9.9 | 40.6 | 49.5
| LWK | 24.5 | 58.2 | 17.3
| MEX | 6.9 | 27.6 | 65.5
| MKK | 19.9 | 50.0 | 30.1
| TSI | 11.8 | 45.1 | 43.1
| HapMapRevision=28
}}rs6929137 increases susceptibility to Bone mineral density variations, lower for carriers of the A allele {{PMID|18445777}}

{{PMID Auto GWAS
|PMID=19079262
|Trait=Bone mineral density (spine)
|Title=New sequence variants associated with bone mineral density
|RiskAllele=A
|Pval=2E-10
|OR=0.10
|ORtxt=[0.07-0.13] SD decrease
}}

{{PharmGKB
|RSID=rs6929137
|Name_s=
|Gene_s=C6orf97
|Feature=
|Evidence=PubMed ID:19079262; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New sequence variants associated with bone mineral density. (Initial Sample Size: 6,865 individuals; Replication Sample Size: 8,510 individuals); (Region: 6q25.1; Reported Gene(s): C6orf97, ESR1; Risk Allele: rs6929137-A); (p-value= 0.0000000002).This variant is associated with Bone mineral density (spine).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740140
}}

{{PMID Auto
|PMID=21528353
|Title=Genetic variants of 6q25 and breast cancer susceptibility: a two-stage fine mapping study in a Chinese population
}}

{{PMID Auto
|PMID=21646926
|Title=Interactions of osteoporosis candidate genes for age at menarche, age at natural menopause, and maximal height in Han Chinese women
}}

{{PMID|19181680|OA=1
}} Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.

{{PMID|20072603|OA=1
}} Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.

{{PMID|20661439|OA=1
}} Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.

{{GET Evidence
|gene=C6ORF97
|aa_change=Val604Ile
|aa_change_short=V604I
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6929137
|overall_frequency_n=3643
|overall_frequency_d=9646
|overall_frequency=0.37767
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=4
|qualitycomment_in_silico=Y
|in_gwas=Y
|in_pharmgkb=Y
|nblosum100=-4
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24481879
|Title=Association of ESR1 and C6orf97 gene polymorphism with osteoporosis in postmenopausal women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}