{{Rsnum
|rsid=696217
|Gene=GHRL
|Chromosome=3
|position=10289773
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=A
|GMAF=0.09045
|Gene_s=GHRL,GHRLOS
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 84.1 | 13.3 | 2.7
| HCB | 69.9 | 27.2 | 2.9
| JPT | 58.4 | 36.3 | 5.3
| YRI | 97.9 | 2.1 | 0.0
| ASW | 91.2 | 8.8 | 0.0
| CHB | 69.9 | 27.2 | 2.9
| CHD | 59.6 | 35.8 | 4.6
| GIH | 90.1 | 9.9 | 0.0
| LWK | 99.1 | 0.9 | 0.0
| MEX | 93.0 | 7.0 | 0.0
| MKK | 92.9 | 7.1 | 0.0
| TSI | 84.3 | 15.7 | 0.0
| HapMapRevision=28
}}

{{omim
|id=605353
|desc=GHRELIN; GHRL
|rsnum=696217
}}

{{PMID Auto
|PMID=20010782
|Title=Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease
}}

{{omim
|id=605353
|rsnum=696217
|variant=0002
}}

{{ClinVar
|rsid=696217
|Reversed=0
|FwdREF=G
|FwdALT=T
|REF=G
|ALT=T
|RSPOS=10331457
|CHROM=3
|GMAF=0.0902
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050168000000150517110101
|GENEINFO=GHRLOS:100126793; GHRL:51738
|GENE_NAME=GHRLOS; GHRL
|GENE_ID=100126793; 51738
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.10331457G>T
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9096; 0.09045
|CLNACC=RCV000005365.1; RCV000005366.1
|CLNDBN=Obesity, age at onset of; Metabolic syndrome, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=605353.0002
|COMMON=1
|Disease=Obesity; Metabolic syndrome
}}

{{PMID Auto
|PMID=16204371
|Title=Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish.
}}

{{PMID Auto
|PMID=16921495
|Title=Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa.
}}

{{PMID Auto
|PMID=17357083
|Title=Medical sequencing at the extremes of human body mass.
|OA=1
}}

{{PMID Auto
|PMID=17389697
|Title=Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.
}}

{{PMID Auto
|PMID=18249219
|Title=Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.
}}

{{PMID Auto
|PMID=18778477
|Title=Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19077438
|Title=Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
|OA=1
}}

{{PMID Auto
|PMID=19593725
|Title=Association of maternally inherited GNAS alleles with African-American male birth weight.
|OA=1
}}

{{PMID Auto
|PMID=20191112
|Title=The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
|OA=1
}}

{{PMID Auto
|PMID=20586762
|Title=Genetic variation of the ghrelin signaling system in females with severe alcohol dependence.
}}

{{PMID Auto
|PMID=21448464
|Title=The ghrelin signalling system is involved in the consumption of sweets.
|OA=1
}}

{{GET Evidence
|gene=GHRL
|aa_change=Leu72Met
|aa_change_short=L72M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs696217
|overall_frequency_n=6
|overall_frequency_d=128
|overall_frequency=0.046875
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|pph2_score=0.974
|nblosum100=-3
|autoscore=4
|webscore=N
}}

{{PMID Auto
|PMID=23257630
|Title=Preproghrelin gene polymorphisms in obese Japanese women. Minor homozygotes are light eaters, do not prefer protein or fat, and apparently have a poor appetite.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}