{{Rsnum
|rsid=6971925
|Gene=DGKB
|Chromosome=7
|position=14406292
|Orientation=plus
|GMAF=0.04729
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DGKB
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 85.0 | 15.0 | 0.0
| JPT | 83.9 | 16.1 | 0.0
| YRI | 97.2 | 2.8 | 0.0
| ASW | 92.9 | 7.1 | 0.0
| CHB | 85.0 | 15.0 | 0.0
| CHD | 86.0 | 13.1 | 0.9
| GIH | 93.8 | 6.2 | 0.0
| LWK | 92.6 | 7.4 | 0.0
| MEX | 84.2 | 15.8 | 0.0
| MKK | 91.5 | 8.5 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19176441
|Trait=Treatment response for acute lymphoblastic leukemia
|Title=Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia
|RiskAllele=T
|Pval=0.000003
|OR=13.91
|ORtxt=[2.72-70.92]
|OA=1
}}

{{PharmGKB
|RSID=rs6971925
|Name_s=
|Gene_s=DGKB
|Feature=
|Evidence=PubMed ID:19176441; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (Initial Sample Size: 487 children; Replication Sample Size: NR); (Region: 7p21.2; Reported Gene(s): DGKB; Risk Allele: rs6971925-T); (p-value= 0.000003).This variant is associated with Treatment response for acute lymphoblastic leukemia.
|Drugs=
|Drug Classes=
|Diseases=Precursor Cell Lymphoblastic Leukemia-Lymphoma
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740031
}}

{{PharmGKB
|RSID=rs6971925
|Name_s=
|Gene_s=DGKB
|Feature=
|Evidence=PubMed ID:19176441
|Annotation=This variant is associated with end-of-induction minimal risidual disease (MRD) in childhood acute lymphoblastic leukemia (ALL) from 2 independent cohorts (GWAS result). Risk Allele: T, MAF= 0.02, combined P value= 3.31E-06.
|Drugs=
|Drug Classes=
|Diseases=Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma
|Curation Level=Curated
|PharmGKB Accession ID=PA162470155
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6971925
|overall_frequency_n=122
|overall_frequency_d=128
|overall_frequency=0.953125
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=105
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}