{{Rsnum
|rsid=6976
|Gene=GLT8D1
|Chromosome=3
|position=52694788
|Orientation=plus
|GMAF=0.3834
|Gene_s=GLT8D1,GNL3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 43.4 | 46.0 | 10.6
| HCB | 25.5 | 56.2 | 18.2
| JPT | 26.5 | 47.8 | 25.7
| YRI | 78.2 | 20.4 | 1.4
| ASW | 63.2 | 35.1 | 1.8
| CHB | 25.5 | 56.2 | 18.2
| CHD | 29.4 | 56.9 | 13.8
| GIH | 53.5 | 40.6 | 5.9
| LWK | 78.2 | 19.1 | 2.7
| MEX | 19.0 | 41.4 | 39.7
| MKK | 84.0 | 15.4 | 0.6
| TSI | 23.5 | 46.1 | 30.4
| HapMapRevision=28
}}Research reported in the Lancet: "identified five genome-wide significant loci (binomial test p≤5·0×10−8) for association with osteoarthritis and three loci just below this threshold. The strongest association was on chromosome 3 with rs6976 (odds ratio 1·12 [95% CI 1·08—1·16]; p=7·24×10−11), which is in perfect linkage disequilibrium with [[rs11177]]. This SNP encodes a missense polymorphism within the nucleostemin-encoding gene GNL3. Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies."
'''Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study
'''[http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60681-3/fulltext]
{{PMID Auto
|PMID=22763110
|Title=Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}