{{Rsnum
|rsid=699
|Gene=AGT
|Chromosome=1
|position=230710048
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.3384
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=AGT
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 43.4 | 37.2
| HCB | 64.2 | 29.9 | 5.8
| JPT | 67.3 | 31.9 | 0.9
| YRI | 85.0 | 15.0 | 0.0
| ASW | 63.2 | 29.8 | 7.0
| CHB | 64.2 | 29.9 | 5.8
| CHD | 62.4 | 31.2 | 6.4
| GIH | 37.6 | 48.5 | 13.9
| LWK | 80.0 | 19.1 | 0.9
| MEX | 46.6 | 44.8 | 8.6
| MKK | 70.5 | 28.2 | 1.3
| TSI | 20.6 | 43.1 | 36.3
| HapMapRevision=28
}}[[rs699]] is a SNP in the angiotensin [[AGT]] gene that encodes a functional change. In most published literature, the name for this SNP is M235T, or perhaps Met235Thr, however its amino acid 268 (not 235) that varies based on the numbering in todays databases. [[rs699]] is also occasionally known as C4072T.

In any case, the [[rs699]](C) allele encodes the threonine variant, which is associated with higher plasma angiotensin levels, and ultimately higher blood pressure leading to increased risk for [[hypertension]] associated disorders.

This association was first reported in 1992 {{PMID|1394429}}, and many studies, though not all, have replicated these findings.{{PMID|11731937|OA=1
}}

[[rs699]] is also (generally) reported to be in tight linkage with [[rs5051]], a neighboring SNP in the promoter of the [[AGT]] gene.

[[rs699]](C) has also been implicated as a risk allele in at least two Caucasian populations for [[pre-eclampsia]] (pregnancy-induced hypertension)[PMID 8513325, PMID 8348146] but did not present a risk in one African population {{PMID|16059745}}.

{{PMID|19108684}} A haplotype of [[rs4311]], [[rs4343]], [[rs699]] increases risk of diabetic nephropathy 4x.

{{ neighbor
| rsid = 4762
| distance = 183
}}

{{Venter SNP
|rsid=699
|allele=G
|frequency=
|uid=1103675360420
|type=heterozygous_SNP
|hugo=AGT
|ensembl gene=ENSG00000135744
|ensembl transcript=ENST00000366667
|sift=TOLERATED
|disease=Defects in AGT are associated with susceptibility to essential hypertension (MIM:145500). Hypertension also occurs in 5-7% of all pregnancies where it is a leading cause of maternal, fetal and neonatal morbidity and mortality. Among pregnancy- induced hypertension cases, severe preeclampsia (MIM:189800) is characterized by the development of hypertension and proteinuria after the 20th week of pregnancy and is the most distinctive, life-threatening form.
}}

{{PMID Auto
|PMID=18653189
|Title=Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort
}}

{{PMID Auto
|PMID=19932491
|Title=Angiotensinogen polymorphisms and acquired [[atrial fibrillation]] in Chinese
}}

{{PharmGKB
|RSID=rs699
|Name_s=AGT:Met235Thr, AGT Met235Thr
|Gene_s=AGT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:14643574
|Annotation=In a retrospective case control study of hypertensive individuals (n=1041), ACE inhibitor use was associated with lower risk of stroke for the C/C (Thr/Thr) genotype of AGT:Met235Thr compared to T (Met) allele carriers. This PGx effect was not seen for myocardial infarction.
|Drugs=
|Drug Classes=ACE INHIBITORS, PLAIN
|Diseases=Hypertension; Myocardial Infarction; Stroke
|Curation Level=Curated
|PharmGKB Accession ID=PA165109819
}}
{{PMID Auto
|PMID=20029521
|Title=The C allele of the AGT Met235Thr polymorphism is associated with power sports performance
}}

{{PMID Auto
|PMID=20185782
|Title=Renin Angiotensin System Gene Polymorphisms and Cerebral Blood Flow Regulation. The MOBILIZE Boston Study
|OA=1
}}

{{PMID Auto
|PMID=20592051
|Title=Interactions among related genes of renin-angiotensin system associated with type 2 diabetes
|OA=1
}}

{{PharmGKB
|RSID=rs699
|Name_s=AGT M235T, AGT:Met235Thr
|Gene_s=AGT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:8728305
|Annotation=The AGT:Met235Thr variant was not associated with response to antihypertensives in a study of 97 hypertensive British individuals.
|Drugs=atenolol; lisinopril; nifedipine
|Drug Classes=
|Diseases=Hypertension
|Curation Level=Curated
|PharmGKB Accession ID=PA165107173
}}

{{PharmGKB
|RSID=rs699
|Name_s=AGT:Met235Thr, angiotensinogen M235T
|Gene_s=AGT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:11593098
|Annotation=Angiotensinogen polymorphism AGT:Met235Thr was not related to the response to antihypertensives in the SILVHIA study of 86 white hypertensive patients.
|Drugs=atenolol; losartan
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165107175
}}
{{PMID Auto
|PMID=20570668
|Title=Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau
}}

{{PMID Auto
|PMID=21261619
|Title=Genetic variation in renin predicts the effects of thiazide diuretics
}}
{{PMID Auto
|PMID=21306748
|Title=The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach
|OA=1
}}

{{omim
|id=106150
|rsnum=699
|variant=0001
}}

{{PMID Auto
|PMID=21988197
|Title=Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis
}}

{{PMID Auto
|PMID=22508051
|Title=Renin-Angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions
}}

{{PMID Auto
|PMID=22531885
|Title=Revising the M235T Polymorphism Position for the AGT Gene and Reporting a Modifying Variant in the Brazilian Population with Potential Cardiac and Neural Impact
}}

{{PMID Auto
|PMID=22569109
|Title=The role of renin-angiotensin-aldosterone system polymorphisms in phenotypic expression of MYBPC3-related hypertrophic cardiomyopathy
|OA=1
}}

{{ClinVar
|rsid=699
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=230710048
|CHROM=1
|GMAF=0.3379
|dbSNPBuildID=36
|SSR=0
|SAO=1
|VP=0x050378000a1517051f110100
|GENEINFO=AGT:183
|GENE_NAME=AGT
|GENE_ID=183
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.230710048A>G
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;TPA;PMC;S3D;SLO;NSM;REF;OTH;ASP;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.3384; 0.6616
|CLNACC=RCV000019691.2; RCV000019692.2; RCV000019693.2
|CLNDBN=Hypertension, essential, susceptibility to; Preeclampsia, susceptibility to; Susceptibility to progression to renal failure in IgA nephropathy
|CLNDSDB=MedGen
|CLNDSDBID=C1862886
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNSRCID=NM_000029.3:c.803T>C; 106150.0001
|COMMON=1
|Disease=Hypertension; Preeclampsia; Susceptibility to progression to renal failure in IgA nephropathy
}}

{{PMID Auto
|PMID=18069999
|Title=Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study.
}}

{{PMID Auto
|PMID=18248681
|Title=Prevalence of common disease-associated variants in Asian Indians.
|OA=1
}}

{{PMID Auto
|PMID=18279468
|Title=Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18637188
|Title=RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population.
|OA=1
}}

{{PMID Auto
|PMID=18698212
|Title=Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=18953568
|Title=Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=20061926
|Title=Randomized controlled trial: lisinopril reduces proteinuria, ammonia, and renal polypeptide tubular catabolism in patients with chronic allograft nephropathy.
}}

{{PMID Auto
|PMID=20486282
|Title=Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.
|OA=1
}}

{{PMID Auto
|PMID=21304999
|Title=Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.
|OA=1
}}

{{PMID Auto
|PMID=21438754
|Title=Gene variation in resistant hypertension: multilocus analysis of the angiotensin 1-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase genes.
}}

{{GET Evidence
|gene=AGT
|aa_change=Met268Thr
|aa_change_short=M268T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs699
|overall_frequency_n=6039
|overall_frequency_d=10758
|overall_frequency=0.56135
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23132613
|Title=Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis
}}

{{PMID Auto
|PMID=23681449
|Title=Genes for Elite Power and Sprint Performance: ACTN3 Leads the Way
}}

{{PMID Auto
|PMID=23681285
|Title=Association of aldosterone synthase (CYP11B2) gene -344T/C polymorphism with the risk of primary chronic glomerulonephritis in the Polish population
}}

{{PMID Auto
|PMID=23716723
|Title=The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population
}}

{{PMID Auto
|PMID=24622918
|Title=Renin-Angiotensin System Genetic Polymorphisms and Brain White Matter Lesions in Older Australians
}}

{{PMID Auto
|PMID=22858200
|Title=Angiotensinogen gene polymorphisms and food-intake behavior in young, normal female subjects in Japan.
}}

{{PMID Auto
|PMID=23021345
|Title=Gene-diet interactions on plasma lipid levels in the Inuit population.
}}

{{PMID Auto
|PMID=23251296
|Title=Assessment of two missense polymorphisms (rs4762 and rs699) of the angiotensinogen gene and stroke.
|OA=1
}}

{{PMID Auto
|PMID=23333443
|Title=Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in Mexican-Mestizo women with severe preeclampsia.
}}

{{PMID Auto
|PMID=23354977
|Title=Human loci involved in drug biotransformation: worldwide genetic variation, population structure, and pharmacogenetic implications.
}}

{{PMID Auto
|PMID=24860821
|Title=Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension: A Case-Control Study
}}

{{PMID Auto
|PMID=25020710
|Title=P324Circadian genes in the regulation of lipids in coronary artery disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}