{{Rsnum
|rsid=6994992
|Gene=NRG1
|Chromosome=8
|position=31638065
|Orientation=plus
|GMAF=0.4412
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NRG1
}}also known as SNP8NRG243177

Initial reports of a link to [[schizophrenia]] remain inconclusive. 

[http://www.jbc.org/cgi/content/abstract/M702953200v1 paper] implicated in schizophrenia

{{PMID|17925794}} effects white matter density and integrity

{{PMID|17565985}} [[schizophrenia]] risk-associated

{{PMID|18286587|OA=1
}} The [[NRG1| neuregulin 1]] promoter polymorphism rs6994992 is '''not''' associated with neurocognition or chronic [[schizophrenia]] in a study of 738 patients

{{PMID|19058791}} T allele (in a per allele fashion) significantly associated with lateral ventricle volume in 95 first-episode schizophrenics

{{PMID|19339916}} points out that their result is that (T) was weakly associated with schizophrenia, however this is the opposite of the original association study where the C allele.

{{omim
|desc=NEUREGULIN 1; NRG1
|id=142445
|rsnum=6994992
}}
{{PMID Auto
|PMID=19913623
|Title=Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia
}}

{{PMID Auto
|PMID=21745728
|Title=Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population
|OA=1
}}

{{PMID Auto
|PMID=17598910
|Title=Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17884806
|Title=Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1.
}}

{{PMID Auto
|PMID=18543275
|Title=A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.
}}

{{PMID Auto
|PMID=19448847
|Title=Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
|OA=1
}}

{{PMID Auto
|PMID=19521112
|Title=Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19594860
|Title=Genes for psychosis and creativity: a promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement.
}}

{{PMID Auto
|PMID=21035784
|Title=The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males.
}}

{{PMID Auto
|PMID=23360725
|Title=Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample
}}

{{PMID Auto
|PMID=24865593
|Title=Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children
}}

{{PMID Auto
|PMID=24123921
|Title=Effects of neuregulin-1 genetic variation and depression symptom severity on longitudinal patterns of psychotic symptoms in primary care attendees
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}