{{Rsnum
|rsid=700651
|Gene=BOLL
|Chromosome=2
|position=197766990
|Orientation=plus
|GMAF=0.3021
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=rs700651 associated with increased risk of developing intracranial aneurysm.
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=BOLL
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 48.6 | 43.2 | 8.1
| HCB | 46.7 | 35.6 | 17.8
| JPT | 22.7 | 54.5 | 22.7
| YRI | 91.8 | 8.2 | 0.0
| ASW | 71.9 | 26.3 | 1.8
| CHB | 46.7 | 35.6 | 17.8
| CHD | 30.8 | 51.4 | 17.8
| GIH | 33.7 | 59.4 | 6.9
| LWK | 88.0 | 11.1 | 0.9
| MEX | 0.0 | 0.0 | 0.0
| MKK | 94.8 | 5.2 | 0.0
| TSI | 65.3 | 31.7 | 3.0
| HapMapRevision=28
}}[http://blog.23andme.com/2008/11/10/snpwatch-study-finds-genetic-links-to-brain-aneurysm-in-both-japanese-and-european-populations/ 23andMe blog] [[aneurysm]]

*[[rs700651]] 	2 	G 	1.18x risk 	1.56x risk
*[[rs10958409]] 8 	A 	1.37x risk 	1.79x risk
*[[rs1333040]] 	9 	T 	1.29x risk 	1.67x risk

{{PMID Auto GWAS
|PMID=18997786
|Trait=Intracranial aneurysm
|Title=Susceptibility loci for intracranial aneurysm in European and Japanese populations
|RiskAllele=G
|Pval=4E-8
|OR=1.24
|ORtxt=[1.15-1.34]
|OA=1
}}

{{omim
|desc=ANEURYSM, INTRACRANIAL BERRY, 9
|id=612586
|rsnum=700651
}}

{{PharmGKB
|RSID=rs700651
|Name_s=
|Gene_s=BOLL
|Feature=
|Evidence=PubMed ID:18997786; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Susceptibility loci for intracranial aneurysm in European and Japanese populations. (Initial Sample Size: 1,580 European cases, 6,276 European controls; Replication Sample Size: 495 Japanese cases, 676 Japanese controls); (Region: 2q33.1; Reported Gene(s): BOLL, PLCL1; Risk Allele: rs700651-G); (p-value= 0.00000004).This variant is associated with Intracranial aneurysm.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740743
}}

{{PMID Auto
|PMID=20395613
|Title=Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs700651
|overall_frequency_n=80
|overall_frequency_d=112
|overall_frequency=0.714286
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

Increased risk of intracranial ([[brain aneurysm]]) with certain SNPs. rs700651(G;G) associated with 1.56x risk of developing an intracranial aneurysm (IA). Heterozygote risk is 1.18x. Other SNPs associated with increased risk of developing IA include [[rs1333040]] and [[rs10958409]]. 

rs10958409 is located on chromosome 9; rs1333040 is located on chromosome 8; rs700651 is located on chromosome 2. 

Unfortunately, the first sign of an [[intracranial aneurysm]] is rupture. Catastrophic bleeding and death may result. Specific knowledge of risk may influence screening decision. More information: Intracranial aneurysm screening: indications and advice for practice.  {{PMID|15664544}}.{{PMID Auto
|PMID=22476622
|Title=Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}