{{Rsnum
|rsid=7014346
|Chromosome=8
|position=127412547
|Orientation=plus
|GMAF=0.326
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=LOC101930033
|Gene_s=LOC101930033
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.0 | 46.0 | 46.0
| HCB | 5.1 | 49.6 | 45.3
| JPT | 2.7 | 31.9 | 65.5
| YRI | 16.4 | 46.6 | 37.0
| ASW | 12.3 | 31.6 | 56.1
| CHB | 5.1 | 49.6 | 45.3
| CHD | 11.9 | 33.0 | 55.0
| GIH | 14.9 | 46.5 | 38.6
| LWK | 15.5 | 48.2 | 36.4
| MEX | 8.8 | 33.3 | 57.9
| MKK | 12.2 | 52.6 | 35.3
| TSI | 11.8 | 39.2 | 49.0
| HapMapRevision=28
}}{{PMID|18839428}} [[colorectal cancer]] [[rs10505477]] and [[rs6983267]] yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively with OR=1.50 (95% CI: 1.29-1.75). Risk region was delineated by SNPs rs10505477 and [[rs7014346]] and comprised 17 kb

{{GWAS Summary
|SNP=rs7014346
|PubMedID=18372901
|Condition=Colorectal cancer
|Gene=POU5FIP1, HsG57825, DQ515897
|Risk Allele=A
|pValue=9.00E-026
|OR=1.19
|95CI=1.15-1.23
|OA=1
}}

{{omim
|desc=COLORECTAL CANCER, SUSCEPTIBILITY TO, 2; CRCS2
|id=611469
|rsnum=7014346
}}

{{PharmGKB
|RSID=rs7014346
|Name_s=
|Gene_s=POU5F1P1
|Feature=
|Evidence=PubMed ID:18372901; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 (Initial Sample Size: 981 cases, 1,002 controls; Replication Sample Size: 16,476 cases, 15,351 controls; Risk Allele: rs7014346-A).
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356763
}}

{{PMID Auto
|PMID=20659471
|Title=Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent
|OA=1
}}
{{PMID Auto
|PMID=21097774
|Title=Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
}}

{{PMID Auto
|PMID=19011631
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19857256
|Title=Association between an 8q24 locus and the risk of colorectal cancer in Japanese.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7014346
|overall_frequency_n=93
|overall_frequency_d=128
|overall_frequency=0.726562
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23359760
|Title=Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
|OA=1
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}