{{Rsnum
|rsid=703842
|Gene=METTL1
|Chromosome=12
|position=57768956
|Orientation=minus
|GMAF=0.4187
|Gene_s=CYP27B1,METTL1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 11.5 | 44.2 | 44.2
| HCB | 41.6 | 47.4 | 10.9
| JPT | 59.3 | 35.4 | 5.3
| YRI | 9.5 | 47.6 | 42.9
| ASW | 14.0 | 54.4 | 31.6
| CHB | 41.6 | 47.4 | 10.9
| CHD | 50.5 | 35.8 | 13.8
| GIH | 27.7 | 48.5 | 23.8
| LWK | 9.1 | 40.0 | 50.9
| MEX | 14.0 | 45.6 | 40.4
| MKK | 3.2 | 29.0 | 67.7
| TSI | 5.0 | 41.6 | 53.5
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19525955
|Trait=Multiple sclerosis
|Title=Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
|RiskAllele=A
|Pval=5E-11
|OR=1.23
|ORtxt=[NR]
}}

{{omim
|id=126200
|rsnum=703842
}}

{{PMID Auto
|PMID=21431378
|Title=Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis
|OA=1
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=18593774
|Title=Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.
|OA=1
}}

{{PMID Auto
|PMID=18689381
|Title=Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19255064
|Title=Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=20018050
|Title=Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data.
|OA=1
}}

{{PMID Auto
|PMID=20368992
|Title=Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.
|OA=1
}}

{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{PMID Auto
|PMID=20648053
|Title=Confirmation of association between multiple sclerosis and CYP27B1.
|OA=1
}}

{{PMID Auto
|PMID=21358824
|Title=Prostate cancer susceptibility Loci identified on chromosome 12 in African Americans.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs703842
|overall_frequency_n=3409
|overall_frequency_d=10758
|overall_frequency=0.31688
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23543094
|Title=Testing for associations between loci and environmental gradients using latent factor mixed models.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}