{{Rsnum
|rsid=705379
|Gene=PON1
|Chromosome=7
|position=95324583
|Orientation=plus
|GMAF=0.3815
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PON1
}}[[rs705379]], also known as -108C/T or -107C/T, is a SNP in the [[PON1]] paraoxonase 1 gene.

{{PMID|11335891|OA=1
}} Variation in the amount of PON1 activity has been reported to primarily involve this SNP, with the following average values of aryesterase activity reported per genotype (sample no. in parentheses):

GG (94)	 125.8 ± 45.6<br>
AG (188) 102.9 ± 37.6<br>
AA (94)	 68.6 ± 27.9<br>

{{PMID Auto
|PMID=20488557
|Title=Decreased serum arylesterase activity in autism spectrum disorders
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19321847
|Title=A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.
|OA=1
}}

{{PMID Auto
|PMID=19401444
|Title=Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.
|OA=1
}}

{{PMID Auto
|PMID=20056567
|Title=Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.
|OA=1
}}

{{PMID Auto
|PMID=21223581
|Title=Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=21543280
|Title=Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.
|OA=1
}}

{{PMID Auto
|PMID=22388798
|Title=Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
|OA=1
}}

{{PMID Auto
|PMID=23167629
|Title=Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review
}}

{{PMID Auto
|PMID=24448003
|Title=Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults
}}

{{PMID Auto
|PMID=22854640
|Title=Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure.
|OA=1
}}

{{PMID Auto
|PMID=22956172
|Title=Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD).
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}