{{Rsnum
|rsid=708272
|Gene=CETP
|Chromosome=16
|position=56962376
|Orientation=minus
|GMAF=0.3792
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CETP
}}[[rs708272]], also known as the TaqIB polymorphism of the [[CETP]] gene, may influence the levels of the "good" cholesterols, the high density lipoprotein (HDL) cholesterols. Generally, the B2 allele is considered to lead to higher HDL levels.

However, high HDL cholesterol, at least when combined with another HDL raising SNP ([[rs1800588]]), doesn't appear to actually protect individuals from [[coronary artery disease]], at least based on one study of ~800 Caucasian male patients. {{PMID|18164013}}

A similarly confusing picture emerges from a study of two populations of 10,000+ individuals each. The distribution of the [[CETP]] genotype was observed to be different in population-based studies compared with studies in populations selected by high cardiovascular risk, and contradictory results were seen when trying to figure out if the TaqIB SNP predicted whether drugs would lower plasma lipids or cardiovascular outcome.{{PMID|18518852}}

A meta-analysis concluded that there probably was a statistically significant, but weak, association for this SNP. For each [[rs708272]](T) allele inherited, individuals had lower mean CETP mass (-9.7%; CI: -11.7% to -7.8%), lower mean CETP activity (-8.6%; CI: -13.0% to -4.1%), higher mean high-density lipoprotein cholesterol (HDL-C) concentrations (4.5%; CI: 3.8%-5.2%), and higher mean apolipoprotein A-I concentrations (2.4%; CI, 1.6%-3.2%). The combined per-allele odds ratios (ORs) for coronary disease were 0.95 (CI: 0.92-0.99).{{PMID|18560005}}

A prospective cohort study of 18,245 initially healthy American women over a 10-year period found similar results with respect to HDL-C levels and (inversely) risk of [[myocardial infarction]]; [[rs708272]](T) was associated with a per-allele increase in HDL-C levels of 3.1 mg/dL and a concordant 24 percent lower risk of future myocardial infarction (age-adjusted HR 0.76, CI: 0.62-0.94).{{doi|10.1161/CIRCGENETICS.108.817304}}

{{omim
|desc=CHOLESTERYL ESTER TRANSFER PROTEIN, PLASMA; CETP
|id=118470
|rsnum=708272
}}

{{PharmGKB
|RSID=rs708272
|Name_s=CETP:Taq1B
|Gene_s=CETP
|Feature=Intron
|Evidence=PubMed ID:14660992; PubMed ID:15044381
|Annotation=In a study of coronary artery disease patients treated with statins the B2 allele was associated with a greater reduction in cardiovascular events compared to the B1 allele.
|Drugs=
|Drug Classes=HMG COA REDUCTASE INHIBITORS
|Diseases=Coronary Artery Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA162361020
}}
{{PMID Auto
|PMID=20031564
|Title=Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction: Genomewide Analysis Among 18 245 Initially Healthy Women From the Women's Genome Health Study
|OA=1
}}

{{PMID Auto
|PMID=20082485
|Title=Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women
|OA=1
}}

{{PMID Auto
|PMID=20489166
|Title=Cholesteryl Ester Transfer Protein Polymorphism (TaqIB) Associates With Risk in Postinfarction Patients With High C-Reactive Protein and High-Density Lipoprotein Cholesterol Levels
|OA=1
}}

{{PharmGKB
|RSID=rs708272
|Name_s=CETP:Taq1B
|Gene_s=CETP
|Feature=Intron
|Evidence=PubMed ID:18239576
|Annotation=Carriers of the CETP:TaqB1 B2 allele are at reduced risk of metabolic syndrome compared to B1 allele..
|Drugs=
|Drug Classes=
|Diseases=Metabolic Syndrome X
|Curation Level=Curated
|PharmGKB Accession ID=PA162361022
}}

{{PharmGKB
|RSID=rs708272
|Name_s=CETP:Taq1B
|Gene_s=CETP
|Feature=Intron
|Evidence=PubMed ID:12639975; PubMed ID:15044381
|Annotation=Meta-analysis of over 10,000 individuals indicates that CETP:Taq1B, B2B2 individuals have higher HDL levels than B1B1 homozygotes.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162361021
}}

{{PharmGKB
|RSID=rs708272
|Name_s=CETP:Taq1B
|Gene_s=CETP
|Feature=Intron
|Evidence=PubMed ID:18560005
|Annotation=Meta-analysis showed weak inverse association with coronary risk for the Taq1B A allele.
|Drugs=
|Drug Classes=
|Diseases=Coronary Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA162361023
}}

{{PMID Auto
|PMID=22011848
|Title=Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels
}}

{{PMID Auto
|PMID=22073289
|Title=Interaction between Cholesteryl Ester Transfer Protein and Hepatic Lipase Encoding Genes and the Risk of Type 2 Diabetes: Results from the Telde Study
|OA=1
}}

{{PMID Auto
|PMID=22143414
|Title=Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort
|OA=1
}}

{{PMID Auto
|PMID=12475937
|Title=Association testing by DNA pooling: an effective initial screen.
|OA=1
}}

{{PMID Auto
|PMID=17157861
|Title=Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults.
|OA=1
}}

{{PMID Auto
|PMID=18275964
|Title=Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study.
|OA=1
}}

{{PMID Auto
|PMID=18549840
|Title=Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke.
|OA=1
}}

{{PMID Auto
|PMID=18637884
|Title=Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction.
|OA=1
}}

{{PMID Auto
|PMID=18835593
|Title=Interactions between alcohol intake and the polymorphism of rs708272 on serum high-density lipoprotein cholesterol levels in the Guangxi Hei Yi Zhuang population.
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19336475
|Title=Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
|OA=1
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19913121
|Title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
|OA=1
}}

{{PMID Auto
|PMID=20205905
|Title=Association of repeatedly measured intermediate risk factors for complex diseases with high dimensional SNP data.
|OA=1
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=21146168
|Title=LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP.
}}

{{PMID Auto
|PMID=21316679
|Title=Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study.
}}

{{PMID Auto
|PMID=21423763
|Title=Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.
|OA=1
}}

{{PMID Auto
|PMID=23351584
|Title=Common variation in cholesteryl ester transfer protein: relationship of first major adverse cardiovascular events with the apolipoprotein B/apolipoprotein A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio
}}

{{PMID Auto
|PMID=24283500
|Title=CETP gene polymorphisms and risk of coronary atherosclerosis in a Chinese population
}}

{{PMID Auto
|PMID=22715478
|Title=Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.
}}

{{PMID Auto
|PMID=23533563
|Title=Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=23675527
|Title=The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.
|OA=1
}}

{{PMID Auto
|PMID=25073458
|Title=CETP Gene Polymorphism in the Caucasian Population of West Siberia and in Groups Contrast by Total Serum Cholesterol Levels
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}