{{Rsnum
|rsid=710521
|Chromosome=3
|position=189928144
|Orientation=minus
|GMAF=0.2305
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 45.1 | 46.9 | 8.0
| HCB | 60.6 | 33.6 | 5.8
| JPT | 59.3 | 35.4 | 5.3
| YRI | 75.5 | 21.8 | 2.7
| ASW | 70.2 | 24.6 | 5.3
| CHB | 60.6 | 33.6 | 5.8
| CHD | 62.4 | 36.7 | 0.9
| GIH | 74.3 | 24.8 | 1.0
| LWK | 63.6 | 34.5 | 1.8
| MEX | 55.2 | 39.7 | 5.2
| MKK | 70.5 | 26.3 | 3.2
| TSI | 53.9 | 38.2 | 7.8
| HapMapRevision=28
}}
[[rs710521]] is a SNP located in chromosome region 3q38, near the [[TP63]] gene.

A study ultimately totaling over 4,000 [[bladder cancer]] patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of [[rs710521]](A) were at 1.4x increased risk (allele-specific odds ratio = 1.19, p = 1 x 10e-7) for the disease.{{PMID|18794855}}

{{PMID|21063684}} An additional 1,425 [[bladder cancer]] patients, supplemented by a meta-analysis of 5,695 additional cases (and 40,000+ controls), did replicate a (somewhat) increased risk associated with the [[rs710521]](A) allele. The overall odds ratio was 1.18 (OR: 1.12 - 1.25, p < 0.0001).

Another study in Chinese populations did not find an increased risk of [[bladder cancer]] for this SNP. {{PMID|19369583}}

{{GWAS Summary
|SNP=rs710521
|PubMedID=18794855
|Condition=Urinary bladder cancer
|Gene=TP63
|Risk Allele=A
|pValue=1.00E-007
|OR=1.19
|95CI=1.12-1.27
}}

{{omim
|desc=BLADDER CANCER
|id=109800
|rsnum=710521
}}

{{PharmGKB
|RSID=rs710521
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18794855; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Sequence variant on 8q24 confers susceptibility to urinary bladder cancer (Initial Sample Size: 1,803 cases, 34,336 controls; Replication Sample Size: 2,165 cases, 3,800 controls; Risk Allele: rs710521-A). This variant is associated with Urinary bladder cancer.
|Drugs=
|Drug Classes=
|Diseases=Urinary Bladder Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356570
}}

{{PMID Auto GWAS
|PMID=20348956
|Trait=Urinary bladder cancer
|Title=A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
|RiskAllele=A
|Pval=6E-8
|OR=1.19
|ORtxt=[1.12-1.27]
|OA=1
}}

{{PMID Auto GWAS
|PMID=20972438
|Trait=None
|Title=A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
|RiskAllele=A
|Pval=2E-10
|OR=1.1800
|ORtxt=[1.12-1.24]
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs710521
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22994575
|Title=Bladder cancer survival in a former industrial area in Saxony-Anhalt, Germany
}}

{{PMID Auto GWAS
  |PMID=24163127
  |Trait=Bladder cancer
  |Title=Genome-wide association study identifies multiple loci associated with bladder cancer risk.
  |RiskAllele=A
  |Pval=2E-11
  |OR=1.14
  |ORtxt=[1.10-1.19]
  }}

{{PMID Auto
|PMID=25218484
|Title=Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}