{{Rsnum
|rsid=713041
|Gene=GPX4
|Chromosome=19
|position=1106616
|Orientation=plus
|ReferenceAllele=T
|GMAF=0.4036
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GPX4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 31.9 | 45.1 | 23.0
| HCB | 27.9 | 49.3 | 22.8
| JPT | 36.6 | 48.2 | 15.2
| YRI | 52.1 | 40.4 | 7.5
| ASW | 54.4 | 38.6 | 7.0
| CHB | 27.9 | 49.3 | 22.8
| CHD | 33.9 | 46.8 | 19.3
| GIH | 25.7 | 53.5 | 20.8
| LWK | 46.8 | 45.0 | 8.3
| MEX | 36.8 | 52.6 | 10.5
| MKK | 24.4 | 54.5 | 21.2
| TSI | 22.5 | 52.0 | 25.5
| HapMapRevision=28
}} 

Two SNPs associated with the antioxidant [[GPX4]] gene, [[rs713041]] and [[rs757229]], are both somewhat correlated (r<sup>2</sup>=0.61) and are associated with all-cause mortality in [[breast cancer]].

The [[rs713041]](T) allele is associated with an increased risk of death following [[breast cancer]] diagnosis, with a hazard ratio of 1.27 per rare allele (CI: 1.13-11.43, p=0.0041).{{PMID|17634480}}

{{PMID Auto
|PMID=20378690
|Title=Genetic variants in selenoprotein genes increase risk of colorectal cancer
}}

{{PMID Auto
|PMID=21733339
|Title=SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease
}}

{{PMID Auto
|PMID=20003265
|Title=Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.
|OA=1
}}

{{PMID Auto
|PMID=20852007
|Title=Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.
}}

{{PMID Auto
|PMID=21459128
|Title=A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells.
|OA=1
}}

{{PMID Auto
|PMID=22139612
|Title=Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand.
|OA=1
}}

{{PMID Auto
|PMID=24499375
|Title=Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}