{{Rsnum
|rsid=7133914
|Gene=LRRK2
|Chromosome=12
|position=40309109
|Orientation=plus
|GMAF=0.09963
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LRRK2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 14.3 | 84.8
| HCB | 0.7 | 9.6 | 89.6
| JPT | 3.6 | 25.5 | 70.9
| YRI | 2.1 | 26.4 | 71.5
| ASW | 3.6 | 23.2 | 73.2
| CHB | 0.7 | 9.6 | 89.6
| CHD | 0.0 | 22.9 | 77.1
| GIH | 0.0 | 11.0 | 89.0
| LWK | 0.0 | 21.1 | 78.9
| MEX | 1.8 | 19.3 | 78.9
| MKK | 1.9 | 32.1 | 66.0
| TSI | 0.0 | 17.2 | 82.8
| HapMapRevision=28
}}{{omim
|desc=LEUCINE-RICH REPEAT KINASE 2; LRRK2
|id=609007
|rsnum=7133914
}}

{{PMID Auto
|PMID=18952485
|Title=Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.
|OA=1
}}

{{PMID Auto
|PMID=20186690
|Title=Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.
}}

{{GET Evidence
|gene=LRRK2
|aa_change=Arg1398His
|aa_change_short=R1398H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7133914
|overall_frequency_n=1002
|overall_frequency_d=10758
|overall_frequency=0.09314
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=1
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23962496
|Title=The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
}}

{{ClinVar
|ALT=A
|CAF=0.9004; 0.09963
|CHROM=12
|CLNACC=RCV000032452.1
|CLNALLE=1
|CLNDBN=Parkinson disease 8, autosomal dominant
|CLNDSDB=GeneReviews:GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1208:NBK1223:C1846862:607060:2828
|CLNHGVS=NC_000012.11:g.40702911G>A
|CLNSRC=GeneReviews
|CLNSRCID=NBK1208
|COMMON=1
|Disease=Parkinson disease 8
|FwdALT=A
|FwdREF=G
|GENEINFO=LRRK2:120892
|GENE_ID=120892
|GENE_NAME=LRRK2
|REF=G
|RSPOS=40702911
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|VC=SNV
|VP=0x05036800000015051f110100
|WGT=0
|dbSNPBuildID=116
|rsid=7133914
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}