{{Rsnum
|rsid=713598
|Gene=TAS2R38
|Chromosome=7
|position=141973545
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.4692
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=MGAM,TAS2R38
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 18.8 | 51.6 | 29.7
| HCB | 46.7 | 42.2 | 11.1
| JPT | 29.5 | 47.7 | 22.7
| YRI | 19.0 | 38.1 | 42.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 46.7 | 42.2 | 11.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs713598]] is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the [[taste]] of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like [[coffee]] and dark beers).

The [[rs713598]](G) allele, in the orientation shown in dbSNP, is the "tasting" allele, and it is dominant to the "non-tasting" allele [[rs713598]](C), so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one [[rs10246939]](C) and one [[rs1726866]](C) allele since, along with [[rs713598]](G), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.{{PMID|12595690}} 

{{ neighbor
| rsid = 1726866
| distance = 640
}}

{{omim
|id=607751
|desc=TASTE RECEPTOR, TYPE 2, MEMBER 38; TAS2R38
|rsnum=713598
}}

{{PMID Auto GWAS
|PMID=20675712
|Trait=None
|Title=The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
|RiskAllele=
|Pval=2E-104
|OR=None
|ORtxt=None
|OA=1
}}

{{omim
|id=607751
|rsnum=713598
|variant=0001
}}

{{ClinVar
|rsid=713598
|Reversed=1
|FwdREF=G
|FwdALT=C
|REF=C
|ALT=G
|RSPOS=141673345
|CHROM=7
|GMAF=0.4698
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05016800000017051f130100
|GENEINFO=TAS2R38:5726
|GENE_NAME=TAS2R38
|GENE_ID=5726
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.141673345C>G
|CLNSIG=6
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.4692; 0.5308
|CLNACC=RCV000003038.1
|CLNDBN=Phenylthiocarbamide tasting
|CLNDSDB=MedGen
|CLNDSDBID=C1868398
|CLNORIGIN=1
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=607751.0001
|COMMON=1
|Disease=Phenylthiocarbamide tasting
}}

{{PMID|15883422}} TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study.

{{PMID|18248681|OA=1
}} Prevalence of common disease-associated variants in Asian Indians.

{{PMID|18834969|OA=1
}} A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.

{{PMID|19092995|OA=1
}} Bitter taste receptors influence glucose homeostasis.

{{PMID|19687126|OA=1
}} A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

{{PMID|19779476|OA=1
}} Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.

{{PMID|21763010}} Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women.

{{GET Evidence
|gene=TAS2R38
|aa_change=Ala49Pro
|aa_change_short=A49P
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs713598
|overall_frequency_n=4638
|overall_frequency_d=10758
|overall_frequency=0.431121
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=3
|n_articles_annotated=3
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|qualityscore_case_control=5
|qualitycomment_case_control=Y
|qualityscore_familial=5
|qualitycomment_familial=Y
|in_omim=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=4
|webscore=N
|variant_evidence=0
|clinical_importance=0
|summary_short=This variant is strongly associated with causing the "taster" phenotype of phenylthiocarbamine (PTC) in a dominant manner.
}}

[[Bitter Taste Perception]]

{{PMID Auto
|PMID=24083639
|Title=Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk
}}

{{PMID Auto
|PMID=23133589
|Title=Bitter taste receptor polymorphisms and human aging.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}