{{Rsnum
|rsid=7158782
|Chromosome=14
|position=95702794
|Orientation=plus
|GMAF=0.3306
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 73.5 | 25.7 | 0.9
| HCB | 68.6 | 27.7 | 3.6
| JPT | 62.5 | 37.5 | 0.0
| YRI | 2.7 | 26.7 | 70.5
| ASW | 5.3 | 49.1 | 45.6
| CHB | 68.6 | 27.7 | 3.6
| CHD | 60.7 | 35.5 | 3.7
| GIH | 76.2 | 21.8 | 2.0
| LWK | 6.4 | 34.9 | 58.7
| MEX | 63.8 | 32.8 | 3.4
| MKK | 11.0 | 41.9 | 47.1
| TSI | 70.6 | 26.5 | 2.9
| HapMapRevision=28
}}[[rs7158782]] is one of 4 SNPs found on chromosome 14 near a gene known as T-cell leukemia/lymphoma 1A ([[TCL1A]]). This gene appears to be estrogen dependent.

In a study of ~300 patients with early-stage estrogen receptor–positive (ER+) [[breast cancer]] who were treated with the aromatase inhibitor (AI) [[anastrozole]] or [[exemestane]] and who developed musculoskeletal toxicity severe enough to prompt discontinuation, [[rs7158782]](G) allele carriers were at ~2x higher risk for toxicity (CI: 1.5 - 2.9, p < 10e-6). The population attributable risk (i.e., the fraction of such adverse events that could be due to this allele) was estimated to be 11%. {{doi|10.1200/JCO.2010.28.5064}}

An editorial accompanying this article downplays the clinical utility of this finding, since testing for this allele, given its frequency and (mere) doubling of risk, has about equal odds of yielding a true positive and a false positive. {{doi|10.1200/JCO.2010.31.2926}}

{{PMID Auto GWAS
|PMID=20876420
|Trait=None
|Title=Genome-Wide Associations and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors
|RiskAllele=
|Pval=8E-7
|OR=2.13
|ORtxt=[1.58-2.87]
|OA=1
}}

{{PMID Auto
|PMID=25035853
|Title=Genotype, allele and haplotype frequencies of four TCL1A gene polymorphisms associated with musculoskeletal toxicity in the South Indian descent
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}