{{Rsnum
|rsid=7183877
|Gene=HERC2
|Chromosome=15
|position=28120587
|Orientation=plus
|GMAF=0.1703
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=HERC2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.9 | 10.6 | 88.5
| HCB | 5.1 | 43.4 | 51.5
| JPT | 9.9 | 46.8 | 43.2
| YRI | 0.7 | 18.4 | 81.0
| ASW | 0.0 | 14.0 | 86.0
| CHB | 5.1 | 43.4 | 51.5
| CHD | 7.4 | 36.1 | 56.5
| GIH | 1.0 | 28.7 | 70.3
| LWK | 0.9 | 8.2 | 90.9
| MEX | 3.4 | 36.2 | 60.3
| MKK | 0.0 | 7.1 | 92.9
| TSI | 4.9 | 25.5 | 69.6
| HapMapRevision=28
}}[[rs7183877]] is part of a haplotype spanning 166kB on chromosome 15, defined by 13 SNPs listed below, found in 97% of all Caucasians with blue eyes. In this haplotype, variations in [[rs1129038]] and [[rs12913832]] are relatively common in Caucasians though rare among other ethnic groups.{{PMID|18172690}}

The "h-1" haplotype found in homozygous state in 97% of individuals with blue [[eye color]] is composed as follows {{PMID|18172690}}:

[[rs4778241]](C)<br>
[[rs1129038]](A)<br>
[[rs12593929]](A)<br>
[[rs12913832]](G)<br>
[[rs7183877]](C)<br>
[[rs3935591]](G)<br>
[[rs7170852]](A)<br>
[[rs2238289]](T)<br>
[[rs3940272]](C)<br>
[[rs8028689]](T)<br>
[[rs2240203]](A)<br>
[[rs11631797]](G)<br>
[[rs916977]](G)<br>

{{ neighbor
| rsid = 12913832
| distance = 115
}}

{{PMID Auto
|PMID=18252221
|Title=Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
|OA=1
}}

{{PMID Auto
|PMID=18483556
|Title=A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
|OA=1
}}

{{PMID Auto
|PMID=20585627
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}