{{Rsnum
|rsid=7213516
|Gene=ANAPC16
|Chromosome=17
|position=63474189
|Orientation=plus
|GMAF=0.04316
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 3.3 | 29.5 | 67.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs7213516]] and [[rs4290]] are SNPs located 2-3 kb upstream of the angiotensin I-converting enzyme ([[ACE]]) gene, and therefore potentially of regulatory importance.

In a study in which 1,000 hypertensive individuals participating in the International Verapamil SR Trandolapril Study Genetic Substudy (INVEST-GENES) were tested for associations with adverse cardiovascular outcomes, both [[rs4290]] and [[rs7213516]] were associated with higher risk. The risk was largely attributable to nonfatal myocardial infarction in African Americans, with an odds ratio of 6.16 (CI: 2.43-15.60, p < 0.0001) for [[rs7213516]]. The high allele frequency of [[rs7213516]](A) in African Americans (16%) compared to Hispanics (4%) and Caucasians (<1%) suggests that these alleles may contribute to ethnic-specific variation in risk. {{PMID|18946466|OA=1
}}

{{PharmGKB
|RSID=rs7213516
|Name_s=
|Gene_s=ACE
|Feature=
|Evidence=PubMed ID:18946466
|Annotation=This variant in the promoter region of ACE was associated with adverse cardiovascular outcomes, largely attributable to nonfatal myocardial infarction in African Americans. The SNP affected transcription in in vitro reporter gene assays.
|Drugs=
|Drug Classes=
|Diseases=Cardiomyopathies; Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA162372857
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7213516
|overall_frequency_n=7
|overall_frequency_d=128
|overall_frequency=0.0546875
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}