{{Rsnum
|rsid=7242
|Gene=SERPINE1
|Chromosome=7
|position=101138164
|Orientation=plus
|GMAF=0.4371
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=SERPINE1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 15.9 | 54.0 | 30.1
| HCB | 19.7 | 50.4 | 29.9
| JPT | 23.2 | 61.6 | 15.2
| YRI | 26.0 | 44.5 | 29.5
| ASW | 29.8 | 42.1 | 28.1
| CHB | 19.7 | 50.4 | 29.9
| CHD | 23.9 | 41.3 | 34.9
| GIH | 10.9 | 55.4 | 33.7
| LWK | 10.0 | 43.6 | 46.4
| MEX | 6.9 | 39.7 | 53.4
| MKK | 12.3 | 44.5 | 43.2
| TSI | 24.5 | 44.1 | 31.4
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs7242
|Name_s=
|Gene_s=SERPINE1
|Feature=
|Evidence=PubMed ID:18794724
|Annotation=The T allele of this variant is more frequent in patients with major depressive disorders (MDD) than in controls in a study consisting of 188 Chinese MDD patients and 346 controls.
|Drugs=
|Drug Classes=
|Diseases=Depression; Depressive Disorder, Major
|Curation Level=Curated
|PharmGKB Accession ID=PA162370401
}}

{{PMID Auto
|PMID=21291465
|Title=The association of genetic polymorphisms with cerebral palsy: a meta-analysis
}}

{{PMID Auto
|PMID=17656673
|Title=Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19360663
|Title=Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=20403199
|Title=High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7242
|overall_frequency_n=61
|overall_frequency_d=126
|overall_frequency=0.484127
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=52
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24355042
|Title=Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency
}}

{{PMID Auto
|PMID=25231632
|Title=Pai-1 Gene Variants and COC Use Are Associated with Stroke Risk: A Case-Control Study in the Han Chinese Women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}