{{Rsnum
|rsid=72547513
|Gene=CYP1A2
|Chromosome=15
|position=74750296
|Orientation=plus
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=CYP1A2
}}[[rs72547513]], also known as 558C>A or F186L, is a SNP in the [[CYP1A2]] gene. In a [http://www.cypalleles.ki.se/cyp1a2.htm CYP database], it is listed as defining the CYP1A2*11 allele. 

23andMe and opensnp show A as more common. dbSNP shows C as the reference, and A as the variant, but no population frequency information is provided. This SNP was originally observed in a Japanese population at a frequency of 0.3%; in an Italian study of 500 healthy individuals, it was not observed.{{PMID|17603224}}

{{PMID|14563787}} claims that A is the variant, and that it defined the CYP1A2*11 allele with a Vmax approximately 5% of that of the CYP1A2 wild type, and reduced enzymatic activity. Two subsequent theoretical studies provide hypotheses for why this change results in lowered activity.{{PMID|21598960}},{{PMID|24464701}}



{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}