{{Rsnum
|rsid=72547517
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Orientation=plus
|Chromosome=15
|position=74754904
|Gene=CYP1A2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=CYP1A2
}}[[rs72547517]], also known as 5166G>A, 5347T>C or R456H, is a SNP in the [[CYP1A2]] gene.

The [[rs72547517]](A) allele defines the CYP1A2*8 variant.

{{PharmGKB
|RSID=rs72547517
|Name_s=CYP1A2:Arg456His, CYP1A2*8, rs72547517 G>A
|Gene_s=CYP1A2
|Feature=
|Evidence=PubMed ID:20125119
|Annotation=Risk or phenotype-associated allele: A Phenotype: In an in vitro system, this variant showed no activity for the drug substrates clozapine or phenacetin even at the highest substrate and double membrane concentrations, it also showed reduced expression of holoprotein in bacterial cells. Type of association: FA
|Drugs=clozapine; phenacetin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165282106
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}