{{Rsnum
|rsid=7255721
|Gene=ADAMTS10
|Chromosome=19
|position=8605046
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.1478
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 57.1 | 31.7 | 11.1
| HCB | 91.1 | 8.9 | 0.0
| JPT | 95.3 | 4.7 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 91.1 | 8.9 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{Venter SNP
|rsid=7255721
|allele=C
|frequency=
|uid=1103691086115
|type=homozygous_SNP
|hugo=ADAMTS10
|ensembl gene=ENSG00000142303
|ensembl transcript=ENST00000270328
|sift=TOLERATED
|disease=Defects in ADAMTS10 are a cause of the autosomal recessive form of Weill-Marchesani syndrome (WMS) (MIM:277600). WMS is characterized by the association of short stature, brachydactyly, joint stiffness, eye anomalies, including microspherophakia, ectopia of the lenses, severe myopia, and glaucoma; and, occasionally, heart defects.
}}

{{PMID Auto
|PMID=19836009
|Title=Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature.
|OA=1
}}

{{GET Evidence
|gene=ADAMTS10
|aa_change=Thr134Ser
|aa_change_short=T134S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7255721
|overall_frequency_n=8368
|overall_frequency_d=10636
|overall_frequency=0.786762
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=80
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|pph2_score=0.001
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-2
|autoscore=3
|n_web_uneval=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}