{{Rsnum
|rsid=72646508
|Gene=PCSK9
|Orientation=plus
|ReferenceAllele=C
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Chromosome=1
|position=55052749
|Gene_s=PCSK9
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs72646508]], also known as L253F, is a SNP in the [[PCSK9]] gene.

It has been reported in several studies (including {{PMID|16554528}} and {{PMID|18354102}}) to be associated with reductions in total cholesterol as well as LDL-C, and most importantly, with significantly lowered risk for coronary events.

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}