{{Rsnum
|rsid=727153
|Chromosome=4
|position=154733269
|Orientation=minus
|GMAF=0.326
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=LRAT
|Gene_s=LRAT
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 22.1 | 52.2 | 25.7
| HCB | 8.8 | 31.4 | 59.9
| JPT | 0.9 | 23.0 | 76.1
| YRI | 2.0 | 34.7 | 63.3
| ASW | 1.8 | 40.4 | 57.9
| CHB | 8.8 | 31.4 | 59.9
| CHD | 6.4 | 28.4 | 65.1
| GIH | 18.8 | 41.6 | 39.6
| LWK | 4.6 | 39.4 | 56.0
| MEX | 13.8 | 32.8 | 53.4
| MKK | 1.3 | 42.9 | 55.8
| TSI | 26.5 | 52.0 | 21.6
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=18823527
|Trait=Alzheimer's disease
|Title=A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
|RiskAllele=C
|Pval=0.0000030000000000000001
|OR=1.63
|ORtxt=[1.37-1.95]
|OA=1
}}

{{PharmGKB
|RSID=rs727153
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18823527; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. (Initial Sample Size: 1,082 cases, 1,239 controls; Replication Sample Size: 1,400 additional controls); (Region: 22q13.33; Reported Gene: CPT1B; Risk Allele: rs727153-C) This variant is associated with Alzheimer's disease.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740888
}}

This SNP is near the gene for lecithin retinol acyltransferase (phosphatidylcholine-retinol O-acetyltransferase) or [[LRAT]], which is involved in [[Vitamin A]] metabolism; the risk allele is reportedly G (in dbSNP orientation). {{PMID|18823527|OA=1
}}

{{PharmGKB
|RSID=rs727153
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18823527; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. (Initial Sample Size: 1,082 cases, 1,239 controls; Replication Sample Size: 1,400 additional controls); (Region: 22q13.33; Reported Gene(s): CPT1B; Risk Allele: rs727153-C); (p-value= 0.000003).This variant is associated with Alzheimer's disease.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740848
}}

{{PMID Auto
|PMID=20574532
|Title=Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs727153
|overall_frequency_n=89
|overall_frequency_d=128
|overall_frequency=0.695312
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=77
|n_articles=1
|n_articles_annotated=1
|qualityscore_case_control=2
|qualitycomment_case_control=Y
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|summary_short=Associated with LOAD (late Onset Alzheimer's disease) . 
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}