{{Rsnum
|rsid=727428
|Gene=SHBG
|Chromosome=17
|position=7634474
|Orientation=minus
|GMAF=0.4646
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.8 | 43.4 | 31.9
| HCB | 27.9 | 51.5 | 20.6
| JPT | 32.1 | 50.9 | 17.0
| YRI | 21.8 | 46.3 | 32.0
| ASW | 28.6 | 50.0 | 21.4
| CHB | 27.9 | 51.5 | 20.6
| CHD | 22.9 | 48.6 | 28.4
| GIH | 34.7 | 48.5 | 16.8
| LWK | 19.1 | 60.9 | 20.0
| MEX | 20.7 | 44.8 | 34.5
| MKK | 34.6 | 46.2 | 19.2
| TSI | 16.7 | 38.2 | 45.1
| HapMapRevision=28
}}[[rs727428]] is a SNP in the sex-hormone binding globulin [[SHBG]] gene. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable. 

{{PMID|21252242|OA=1
}} Based on a study of 758 women in 430 families, [[rs727428]] is associated with levels of that sex-hormone binding globulin hormone, independent of the effects of insulin resistance and obesity. Specifically, levels of SHBG were decreased approximately 13% in (A;G) heterozygotes and 27% in (A;A) homozygotes compared with (G;G) homozygotes. [Note: designation of alleles is as shown in dbSNP.] 

{{PMID|19064566|OA=1
}} Haplotype analysis suggested that [[rs858518]], [[rs727428]], or a variant in linkage disequilibrium with them acts to decrease SHBG levels but that this effect is neutralized by [[rs6259]]. 

This SNP was previously associated with risk of type 2 diabetes mellitus.

{{PMID Auto
|PMID=22675492
|Title=Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women
|OA=1
}}

{{PMID Auto
|PMID=12466288
|Title=Haplotype and linkage disequilibrium architecture for human cancer-associated genes.
|OA=1
}}

{{PMID Auto
|PMID=17411440
|Title=Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=22936694
  |Trait=Androgen levels
  |Title=Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.
  |RiskAllele=T
  |Pval=1E-12
  |OR=.07
  |ORtxt=[0.053-0.093] unit decrease
  |OA=1
}}

{{PMID Auto
|PMID=23001781
|Title=Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}