{{Rsnum
|rsid=7278737
|Gene=LIPI
|Chromosome=21
|position=14109044
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=A
|GMAF=0.4959
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=LIPI
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 23.9 | 50.4 | 25.7
| HCB | 27.9 | 53.7 | 18.4
| JPT | 26.5 | 53.1 | 20.4
| YRI | 26.5 | 49.0 | 24.5
| ASW | 24.6 | 45.6 | 29.8
| CHB | 27.9 | 53.7 | 18.4
| CHD | 21.3 | 55.6 | 23.1
| GIH | 23.8 | 55.4 | 20.8
| LWK | 18.2 | 48.2 | 33.6
| MEX | 13.8 | 58.6 | 27.6
| MKK | 23.7 | 55.8 | 20.5
| TSI | 35.3 | 45.1 | 19.6
| HapMapRevision=28
}}{{Venter SNP
|rsid=7278737
|allele=T
|frequency=0.492
|uid=1103643073582
|type=homozygous_SNP
|hugo=LIPI
|ensembl gene=ENSG00000188992
|ensembl transcript=ENST00000344577
|sift=TOLERATED
|disease=Defects in LIPI may be a cause of susceptibility to familial hypertrigliceridemia (MIM:145750). Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
}}

{{GET Evidence
|gene=LIPI
|aa_change=Asp465Glu
|aa_change_short=D465E
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7278737
|overall_frequency_n=5378
|overall_frequency_d=10754
|overall_frequency=0.500093
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=0
|n_articles_annotated=0
|nblosum100=-2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}