{{Rsnum
|rsid=727957
|Gene=KCNE1
|Chromosome=21
|position=34507774
|Orientation=plus
|GMAF=0.08127
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=KCNE1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 60.2 | 36.3 | 3.5
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 99.3 | 0.7 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 59.4 | 34.7 | 5.9
| LWK | 99.1 | 0.9 | 0.0
| MEX | 79.3 | 20.7 | 0.0
| MKK | 98.7 | 1.3 | 0.0
| TSI | 70.6 | 26.5 | 2.9
| HapMapRevision=28
}}
[http://blog.23andme.com/2009/03/23/snpwatch-researchers-identify-genetic-variants-linked-to-heart-rhythm-and-possibly-sudden-cardiac-death/ 23andMe blog] Influences [[QT interval]]

{{PharmGKB
|RSID=rs727957
|Name_s=KCNE1:rs727957
|Gene_s=KCNE1
|Feature=
|Evidence=PubMed ID:15746444
|Annotation=Associated with altered myocardial repolarization.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145084
}}

{{PMID Auto GWAS
|PMID=20062063
|Trait=Electrocardiographic traits
|Title=Several common variants modulate heart rate, PR interval and QRS duration
|RiskAllele=T
|Pval=2E-12
|OR=11.70
|ORtxt=[8.46-14.94] % SD increase
}}

{{PMID Auto
|PMID=18674739
|Title=Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study.
}}

{{PMID Auto
|PMID=19587794
|Title=Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs727957
|overall_frequency_n=15
|overall_frequency_d=128
|overall_frequency=0.117188
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
|summary_short=may influence cardiac repolarization and cardiovascular mortality
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}