{{Rsnum
|rsid=728524
|Gene=ESR1
|Chromosome=6
|position=151982302
|Orientation=plus
|GMAF=0.123
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ESR1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 92.2 | 7.8 | 0.0
| HCB | 62.2 | 35.6 | 2.2
| JPT | 68.2 | 22.7 | 9.1
| YRI | 61.3 | 30.6 | 8.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 62.2 | 35.6 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{PMID|17889406|OA=1
}}
Among women [[rs8179176]] [[rs9340799]] [[rs1256065]] and [[rs1256030]] were associated with likelihood of developing cognitive impairment. In men, one of the [[rs728524]] [[rs1255998]] [[rs1256030]] were associated with cognitive impairment.

{{PharmGKB
|RSID=rs728524
|Name_s=ESR1:rs728524
|Gene_s=ESR1
|Feature=
|Evidence=PubMed ID:16949384; PubMed ID:16949390; PubMed ID:16949392; PubMed ID:16949394
|Annotation=Associated with cognitive function and cholesterol levels in some groups.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145056
}}

{{PMID Auto
|PMID=19630952
|Title=Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs728524
|overall_frequency_n=19
|overall_frequency_d=128
|overall_frequency=0.148438
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}