{{Rsnum
|rsid=729302
|Chromosome=7
|position=128928906
|Orientation=plus
|GMAF=0.2723
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 46.0 | 46.0 | 8.0
| HCB | 36.5 | 46.0 | 17.5
| JPT | 56.6 | 38.9 | 4.4
| YRI | 71.4 | 27.2 | 1.4
| ASW | 56.1 | 35.1 | 8.8
| CHB | 36.5 | 46.0 | 17.5
| CHD | 37.6 | 49.5 | 12.8
| GIH | 48.5 | 38.6 | 12.9
| LWK | 61.8 | 36.4 | 1.8
| MEX | 63.8 | 29.3 | 6.9
| MKK | 66.7 | 31.4 | 1.9
| TSI | 52.9 | 41.2 | 5.9
| HapMapRevision=28
}}{{PMID|18063667}} A variant located 64 bp upstream of the first untranslated exon (exon 1A), consisting of a 5 bp insertion/deletion CGGGG, may be the causative SNP in this region that is most responsible for increasing SLE risk, however it lacks an rs# (i.e. it isn't registered in dbSNP).

{{PMID|19228650}} A meta-analysis comprising 5 case-control studies, totaling 6,582 [[rheumatoid arthritis]] cases and 5,375 controls, concluded that several [[IRF5]] gene SNPs were indeed (still) significantly associated with the disease. The [[rs729302]](C) allele was associated with a slight protective effect (odds ratio 0.89, CI: 0.8-0.977, p = 0.015).

{{PMID Auto
|PMID=21239750
|Title=Association of IRF5 Polymorphisms with Susceptibility to Macrophage Activation Syndrome in Patients with Juvenile Idiopathic Arthritis
}}

{{PMID Auto
|PMID=15657875
|Title=Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=17389033
|Title=Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population.
|OA=1
}}

{{PMID Auto
|PMID=17412832
|Title=Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
|OA=1
}}

{{PMID Auto
|PMID=17568788
|Title=Opposed independent effects and epistasis in the complex association of IRF5 to SLE.
}}

{{PMID Auto
|PMID=18285424
|Title=Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.
|OA=1
}}

{{PMID Auto
|PMID=18408250
|Title=A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.
}}

{{PMID Auto
|PMID=20169177
|Title=Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=20479942
|Title=Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.
|OA=1
}}

{{PMID Auto
|PMID=21834935
|Title=A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus.
}}

{{PMID Auto
|PMID=21898142
|Title=Association of IRF5 polymorphisms with susceptibility to hemophagocytic lymphohistiocytosis in children.
}}

{{PMID Auto
|PMID=23073787
|Title=Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis
}}

{{PMID Auto GWAS
  |PMID=23053960
  |Trait=Systemic lupus erythematosus
  |Title=Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
  |RiskAllele=A
  |Pval=4E-8
  |OR=1.29
  |ORtxt=[1.41-1.18]
  }}

{{PMID Auto GWAS
  |PMID=23273568
  |Trait=Systemic lupus erythematosus
  |Title=Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
  |RiskAllele=A
  |Pval=1E-9
  |OR=1.47
  |ORtxt=
  |OA=1
}}

{{PMID Auto
|PMID=23288367
|Title=Interferon regulatory factor 5 polymorphisms in sarcoidosis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}