{{Rsnum
|rsid=7297245
|Gene=HAL
|Chromosome=12
|position=95980836
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1093
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HAL
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 33.6 | 62.8
| HCB | 0.0 | 8.1 | 91.9
| JPT | 0.0 | 6.2 | 93.8
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 12.3 | 87.7
| CHB | 0.0 | 8.1 | 91.9
| CHD | 0.0 | 8.3 | 91.7
| GIH | 0.0 | 20.8 | 79.2
| LWK | 0.0 | 0.0 | 0.0
| MEX | 1.8 | 24.6 | 73.7
| MKK | 0.0 | 7.1 | 92.9
| TSI | 2.9 | 33.3 | 63.7
| HapMapRevision=28
}}

{{Venter SNP
|rsid=7297245
|allele=T
|frequency=
|uid=1103649514553
|type=homozygous_SNP
|hugo=HAL
|ensembl gene=ENSG00000084110
|ensembl transcript=ENST00000261208
|sift=TOLERATED
|disease=Defects in HAL are the cause of histidinemia (MIM:235800). It is an autosomal recessive disease characterized by increased histidine and histamine as well as decreased urocanic acid in body fluids.
}}

{{PMID Auto
|PMID=18641401
|Title=A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions.
|OA=1
}}

{{PMID Auto
|PMID=18853455
|Title=Whole genome survey of coding SNPs reveals a reproducible pathway determinant of Parkinson disease.
|OA=1
}}

{{GET Evidence
|gene=HAL
|aa_change=Val439Ile
|aa_change_short=V439I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7297245
|overall_frequency_n=9087
|overall_frequency_d=10758
|overall_frequency=0.844674
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=97
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-4
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}