{{Rsnum
|rsid=7297610
|Chromosome=12
|position=69430244
|Orientation=plus
|GMAF=0.1061
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 85.0 | 14.2 | 0.9
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 39.5 | 46.9 | 13.6
| ASW | 47.4 | 52.6 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 93.1 | 6.9 | 0.0
| LWK | 47.3 | 44.5 | 8.2
| MEX | 87.9 | 10.3 | 1.7
| MKK | 55.1 | 39.7 | 5.1
| TSI | 80.4 | 17.6 | 2.0
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs317689,rs315135,rs7297610
|PubMedID=18591461
|Condition=Response to diuretic therapy
|Gene=LYZ, YEATS4, FRS2
|Risk Allele=e
|pValue=6.00E-006
|OR=NA
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs7297610
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18591461; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic (Initial Sample Size: 194 blacks, 195 whites; Replication Sample Size: NR). This variant is associated with Response to diuretic therapy.
|Drugs=hydrochlorothiazide
|Drug Classes=THIAZIDE DERIVATIVES
|Diseases=Hypertension
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356545
}}

{{PMID|22350108|OA=1
}} Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7297610
|overall_frequency_n=21
|overall_frequency_d=126
|overall_frequency=0.166667
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}