{{Rsnum
|rsid=730012
|Gene=LTC4S
|Chromosome=5
|position=179793637
|Orientation=plus
|GMAF=0.1993
|Gene_s=LOC100289556,LTC4S
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 46.9 | 42.5 | 10.6
| HCB | 72.8 | 25.7 | 1.5
| JPT | 68.1 | 28.3 | 3.5
| YRI | 98.6 | 1.4 | 0.0
| ASW | 87.7 | 12.3 | 0.0
| CHB | 72.8 | 25.7 | 1.5
| CHD | 78.0 | 22.0 | 0.0
| GIH | 65.7 | 31.3 | 3.0
| LWK | 87.3 | 12.7 | 0.0
| MEX | 60.3 | 36.2 | 3.4
| MKK | 85.3 | 14.7 | 0.0
| TSI | 55.4 | 37.6 | 6.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs730012
|Name_s=LTC4S: A-444C
|Gene_s=LTC4S
|Feature=Intron
|Evidence=PubMed ID:19862937
|Annotation=Risk or phenotype-associated allele: C. Phenotype: A-444C was associated with aspirin-induced urticaria (AIU). The C allele was more frequent in patients with the cutaneous pattern of AIU and in patients with low skin reactivity to histamine. Study size: 110 patients with AIU and 165 nonallergic controls .
|Drugs=aspirin
|Drug Classes=
|Diseases=Urticaria
|Curation Level=Curated
|PharmGKB Accession ID=PA165110400
}}

{{PharmGKB
|RSID=rs730012
|Name_s=LTC4S:-444C
|Gene_s=LTC4S
|Feature=Intron
|Evidence=PubMed ID:16433794
|Annotation=A two-family study indicates that aspirin-induced urticaria aggregates in families in which the C allele of this SNP is present.
|Drugs=aspirin
|Drug Classes=
|Diseases=Urticaria
|Curation Level=Curated
|PharmGKB Accession ID=PA162355846
}}

{{PharmGKB
|RSID=rs730012
|Name_s=LTC4S (rs730012)
|Gene_s=LTC4S
|Feature=Intron
|Evidence=PubMed ID:16293801
|Annotation=Associations were found between LTC4S (rs730012) and LTA4H (rs2660845) and exacerbation rates in asthma patients treated with montelukast.
|Drugs=montelukast
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA162652701
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=18366797
|Title=Influence of leukotriene gene polymorphisms on chronic rhinosinusitis.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19214143
|Title=5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.
|OA=1
}}

{{PMID Auto
|PMID=19223558
|Title=Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19665766
|Title=Genetics and pharmacogenetics of the leukotriene pathway.
|OA=1
}}

{{PMID Auto
|PMID=20031584
|Title=Genetics of atherothrombotic and lacunar stroke.
|OA=1
}}

{{PMID Auto
|PMID=20592916
|Title=Pharmacogenomic approaches to asthma treatment.
|OA=1
}}

{{PMID Auto
|PMID=23079278
|Title=Genetic variation in members of the leukotrienes biosynthesis pathway confers risk of ischemic stroke in Eastern Han Chinese
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs730012
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=3
|n_articles_annotated=3
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}