{{Rsnum
|rsid=7301328
|Gene=GRIN2B
|Chromosome=12
|position=13865843
|Orientation=plus
|GMAF=0.4036
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=GRIN2B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 12.9 | 50.0 | 37.1
| HCB | 33.3 | 35.6 | 31.1
| JPT | 20.9 | 44.2 | 34.9
| YRI | 21.0 | 46.8 | 32.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 33.3 | 35.6 | 31.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs7301328]] ( 366C/G / Pro122Pro ) is a SNP within [[GRIN2B]] (Glutamate [NMDA] receptor subunit epsilon-2).

{{PMID|19562769}} small study (consisting of 404 Parkinson's patients) found association of the CC genotype with increased incidence of impulsive control and related behaviors

no assoc. noted with<br>
{{PMID|19605943}} lithium response and {{PMID|19005876}} bipolar disorder with any GRIN2B SNPs tested ([[rs7301328|366G/C]], [[rs1019385|-200G/T]] and [[rs890]])<br>
{{PMID|15542698}} alcoholism<br>
{{PMID|12824739}} treatment-refractory schizophrenia - 'not a major risk factor', higher mean clozapine dosage noted with the [[rs1806201]](C;C) genotype

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=20537720
|Title=Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population.
}}

{{PMID Auto
|PMID=24114429
|Title=A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression
}}

{{PMID Auto
|PMID=23408766
|Title=Assessment of NMDA receptor genes (GRIN2A, GRIN2B and GRIN2C) as candidate genes in the development of degenerative lumbar scoliosis.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}