{{Rsnum
|rsid=7305115
|Gene=TPH2
|Chromosome=12
|position=71979082
|Orientation=plus
|ReferenceAllele=A
|GMAF=0.4734
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TPH2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.0 | 37.5 | 45.5
| HCB | 22.1 | 51.5 | 26.5
| JPT | 20.4 | 46.0 | 33.6
| YRI | 11.6 | 44.2 | 44.2
| ASW | 10.5 | 50.9 | 38.6
| CHB | 22.1 | 51.5 | 26.5
| CHD | 30.6 | 55.6 | 13.9
| GIH | 21.8 | 48.5 | 29.7
| LWK | 27.3 | 48.2 | 24.5
| MEX | 24.1 | 53.4 | 22.4
| MKK | 21.2 | 53.2 | 25.6
| TSI | 26.5 | 42.2 | 31.4
| HapMapRevision=28
}}
{{PMID|17011525}} Effect of [[rs7305115]] on susceptibility to [[suicide]].

{{PMID Auto
|PMID=19763617
|Title=Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease
}}

{{PharmGKB
|RSID=rs7305115
|Name_s=TPH2: Pro312Pro
|Gene_s=TPH2
|Feature=
|Evidence=PubMed ID:17453063
|Annotation=This SNP affects the TPH2 expression in human pons.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162190495
}}

{{PMID Auto
|PMID=20738857
|Title=Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression
|OA=1
}}

{{PMID Auto
|PMID=21620479
|Title=Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population
}}

{{PMID Auto
|PMID=21969281
|Title=Influence of birth weight on internalizing traits modulated by serotonergic genes
}}

{{PMID Auto
|PMID=17649681
|Title=[A case-control study on the risk factors for attempted suicide in patients with major depression].
}}

{{PMID Auto
|PMID=18439448
|Title=Stress, genes and the biology of suicidal behavior.
|OA=1
}}

{{PMID Auto
|PMID=18698231
|Title=Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{PMID Auto
|PMID=20126463
|Title=Alternative splicing and extensive RNA editing of human TPH2 transcripts.
|OA=1
}}

{{PMID Auto
|PMID=20403506
|Title=Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.
|OA=1
}}

{{PMID Auto
|PMID=20938755
|Title=Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21937687
|Title=Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7305115
|overall_frequency_n=6264
|overall_frequency_d=10758
|overall_frequency=0.582264
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=77
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22655589
|Title=Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.
}}

{{PMID Auto
|PMID=23628433
|Title=Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.
}}

{{PMID Auto
|PMID=25214390
|Title=Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}