{{Rsnum
|rsid=7310409
|Gene=HNF1A
|Chromosome=12
|position=120987058
|Orientation=plus
|GMAF=0.3935
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HNF1A
}}A study of 12,854 Japanese subjects replicated the finding of an association between [[rs7310409]] and serum CRP levels.{{PMID|21196492}}

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.9 | 52.2 | 31.9
| HCB | 16.1 | 49.6 | 34.3
| JPT | 24.8 | 57.5 | 17.7
| YRI | 9.5 | 40.8 | 49.7
| ASW | 10.5 | 45.6 | 43.9
| CHB | 16.1 | 49.6 | 34.3
| CHD | 14.7 | 42.2 | 43.1
| GIH | 28.7 | 42.6 | 28.7
| LWK | 5.5 | 30.9 | 63.6
| MEX | 13.8 | 44.8 | 41.4
| MKK | 8.5 | 45.1 | 46.4
| TSI | 16.7 | 51.0 | 32.4
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs7310409
|PubMedID=18439548
|Condition=C-reactive protein
|Gene=HNF1A
|Risk Allele=A
|pValue=7.00E-017
|OR=0.15
|95CI=NR) mg/dl decreas
|OA=1
}}

{{PharmGKB
|RSID=rs7310409
|Name_s=
|Gene_s=HNF1A
|Feature=
|Evidence=PubMed ID:18439548; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study (Initial Sample Size: 6,345 women; Replication Sample Size: NR; Risk Allele: rs7310409-A). This variant is associated with C-reactive protein levels.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Metabolic Syndrome X; Myocardial Infarction; Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356793
}}

{{PharmGKB
|RSID=rs7310409
|Name_s=
|Gene_s=HNF1A
|Feature=
|Evidence=PubMed ID:18439548
|Annotation=In a GWAS of apparently healthy women, seven loci were found to be significantly associated with C-Reactive protein levels. Eight SNPs in HNF1A were significantly associated with CRP levels, and of these, this SNP showed the most significant association.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161614223
}}

{{PMID Auto GWAS
|PMID=21196492
|Trait=None
|Title=Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus
|RiskAllele=G
|Pval=3E-8
|OR=0.0700
|ORtxt=[0.04-0.10] unit increase
}}

{{PMID Auto GWAS
|PMID=22001757
|Trait=None
|Title=Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|RiskAllele=G
|Pval=7E-45
|OR=6.8000
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=18439552
|Title=Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=20031577
|Title=Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=21195701
|Title=Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese.
}}

{{PMID Auto
|PMID=21498636
|Title=Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus.
|OA=1
}}

{{PMID Auto
|PMID=21647738
|Title=Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|OA=1
}}

{{PMID Auto
|PMID=22569176
|Title=MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7310409
|overall_frequency_n=76
|overall_frequency_d=124
|overall_frequency=0.612903
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=63
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23092954
|Title=SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
|OA=1
}}

{{PMID Auto
|PMID=23183503
|Title=Variants within HNF1alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}