{{Rsnum
|rsid=7311358
|Gene=SLCO1B3
|Chromosome=12
|position=20862826
|Orientation=plus
|GMAF=0.2906
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SLCO1B3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 75.0 | 25.0 | 0.0
| HCB | 55.8 | 37.2 | 7.0
| JPT | 59.5 | 23.8 | 16.7
| YRI | 11.1 | 42.9 | 46.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 55.8 | 37.2 | 7.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs7311358
|Name_s=SCLO1B3: exon 7 c.699G>A, mRNA 825G>A, p.Met233Ile
|Gene_s=SLCO1B3
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19890249
|Annotation=Risk or phenotype-associated allele: SCLO1B3 haplotype formed by 112Ser>Ala (rs4149117, 334T>G) and 223Met>Ile (rs7311358, 699G>A). Phenotype: HEK293 cells transiently expressing the SCLO1B3 334G-699A haplotype or reference haplotype were incubated in the presence of increasing concentrations of mycophenolic acid phenyl-glucuronide (MPAG) for 10 min. The uptake of MPAG according to the SCLO1B3 334G-699A haplotype was markedly lower than in cells expressing the reference sequence 334T-669G. Type of association: GN; FA; PK
|Drugs=cyclosporine; mycophenolate mofetil; sirolimus; tacrolimus
|Drug Classes=
|Diseases=Organ Transplantation
|Curation Level=Curated
|PharmGKB Accession ID=PA165109799
}}

{{PMID Auto
|PMID=22136368
|Title=Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.
}}

{{GET Evidence
|gene=SLCO1B3
|aa_change=Met233Ile
|aa_change_short=M233I
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7311358
|overall_frequency_n=7725
|overall_frequency_d=10758
|overall_frequency=0.71807
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=74
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.131
|nblosum100=-1
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23133420
|Title=Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}