{{Rsnum
|rsid=733618
|Gene=CTLA4
|Chromosome=2
|position=203866221
|Orientation=minus
|GMAF=0.1708
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CTLA4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 89.4 | 8.8 | 1.8
| HCB | 39.4 | 44.5 | 16.1
| JPT | 36.3 | 47.8 | 15.9
| YRI | 72.8 | 25.2 | 2.0
| ASW | 78.9 | 15.8 | 5.3
| CHB | 39.4 | 44.5 | 16.1
| CHD | 37.6 | 46.8 | 15.6
| GIH | 78.2 | 20.8 | 1.0
| LWK | 69.1 | 27.3 | 3.6
| MEX | 86.2 | 13.8 | 0.0
| MKK | 67.9 | 27.6 | 4.5
| TSI | 92.2 | 7.8 | 0.0
| HapMapRevision=28
}}[[rs733618]], also known as T/C-1772, is a SNP in the upstream activator sequence of the cytotoxic T lymphocyte associated antigen-4 [[CTLA4]] gene. This gene encodes the CD152 antigen.

A study of 165 Swedish [[myasthenia gravis]] patients concluded that the [[rs733618]](A;G) heterozygotes had an odds ratio of 1.87 (CI: 1.01-3.49, p=0.049) for the disease compared to healthy individuals, yet neither allele on its own showed increased risk.{{PMID|18088253}}

{{PMID|18059468}} [[rs231775]] (CTLA4_+49_G/A P=0.0219) and [[rs733618]] (CTLA4_-1722_T/C P=0.0096) susceptibility to [[Graves' disease]]

{{ neighbor
| rsid = 11571316
| distance = 145
}}

{{ neighbor
| rsid = 4553808
| distance = 61
}}

{{PMID Auto
|PMID=21513760
|Title=Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population
}}

{{PMID Auto
|PMID=15452244
|Title=Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
|OA=1
}}

{{PMID Auto
|PMID=18528295
|Title=Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade.
|OA=1
}}

{{PMID Auto
|PMID=19264973
|Title=Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
|OA=1
}}

{{PMID Auto
|PMID=19300490
|Title=An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19500380
|Title=LD2SNPing: linkage disequilibrium plotter and RFLP enzyme mining for tag SNPs.
|OA=1
}}

{{PMID Auto
|PMID=19609446
|Title=CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.
|OA=1
}}

{{PMID Auto
|PMID=19622768
|Title=CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.
|OA=1
}}

{{PMID Auto
|PMID=19956097
|Title=Remapping the type I diabetes association of the CTLA4 locus.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=20018068
|Title=A comparison of case-only designs for detecting gene x gene interaction in rheumatoid arthritis using genome-wide case-control data in Genetic Analysis Workshop 16.
|OA=1
}}

{{PMID Auto
|PMID=20557968
|Title=Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
}}

{{PMID Auto
|PMID=22288822
|Title=A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis.
|OA=1
}}

{{PMID Auto
|PMID=22418270
|Title=Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients.
}}

{{PMID Auto
|PMID=24015180
|Title=CTLA4 Gene Polymorphisms Influence the Incidence of Infection after Renal Transplantation in Chinese Recipients
|OA=1
}}

{{PMID Auto
|PMID=23628397
|Title=Lack of association between CTLA-4 and PDCD1 polymorphisms and acute rejection in German liver transplant recipients
}}

{{PMID Auto
|PMID=23261408
|Title=-1722T/C polymorphism (rs733618) of CTLA-4 significantly associated with systemic lupus erythematosus (SLE): a comprehensive meta-analysis.
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}