{{Rsnum
|rsid=7341475
|Gene=RELN
|Chromosome=7
|position=103764368
|Orientation=plus
|GMAF=0.157
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=RELN
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 23.0 | 74.3
| HCB | 0.0 | 19.7 | 80.3
| JPT | 2.7 | 20.4 | 77.0
| YRI | 0.7 | 32.2 | 67.1
| ASW | 0.0 | 19.3 | 80.7
| CHB | 0.0 | 19.7 | 80.3
| CHD | 0.0 | 10.1 | 89.9
| GIH | 2.0 | 26.7 | 71.3
| LWK | 2.7 | 30.9 | 66.4
| MEX | 6.9 | 31.0 | 62.1
| MKK | 4.5 | 36.5 | 59.0
| TSI | 3.9 | 28.4 | 67.6
| HapMapRevision=28
}}

A total of 2,274 cases of [[schizophrenia]] were studied, resulting in an association between [[rs7341475]], exclusively in women. Based on all populations the estimated relative risk for women carrying the common (G;G) genotype is 1.58 (p = 8.8 x 10(<sup>-7</sup>).{{PMID|18282107|OA=1
}}

This finding was replicated in a large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female), with confirmation that it applies to both [[schizophrenia]] and schizoaffective disorder.{{PMID|20431428|OA=1
}}

{{PharmGKB
|RSID=rs7341475
|Name_s=
|Gene_s=RELN
|Feature=
|Evidence=PubMed ID:18282107; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women. (Initial Sample Size: 660 cases, 2,271 controls; Replication Sample Size: 2,274 cases, 4,401 controls); (Region: 7q22.1; Reported Gene(s): RELN; Risk Allele: rs7341475-G); (p-value= 8.99999999999999E-07).This variant is associated with Schizophrenia.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740860
}}

{{PMID Auto
|PMID=21603580
|Title=The genetic variation of RELN expression in schizophrenia and bipolar disorder
|OA=1
}}

{{PMID Auto
|PMID=22006801
|Title=[Association of RELN SNP rs7341475 with schizophrenia in the Chinese population]
}}

{{PMID Auto
|PMID=19002143
|Title=Sex-specific genetic architecture of human disease.
|OA=1
}}

{{PMID Auto
|PMID=19197363
|Title=A genome-wide investigation of SNPs and CNVs in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=20434133
|Title=No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression.
|OA=1
}}

{{PMID Auto
|PMID=20468075
|Title=Further investigation of the association between rs7341475 and rs17746501 and schizophrenia.
}}

{{PMID Auto
|PMID=20485477
|Title=New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
|OA=1
}}

{{PMID Auto
|PMID=21195391
|Title=Association of reelin (RELN) single nucleotide polymorphism rs7341475 with prepulse inhibition in the Jewish Israeli population.
}}

{{PMID Auto
|PMID=21745129
|Title=Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7341475
|overall_frequency_n=19
|overall_frequency_d=128
|overall_frequency=0.148438
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=5
|n_articles_annotated=5
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|summary_short=susceptibility to bipolar and schizophrenia possibly specific to Ashkenazi Jews. 
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}