{{Rsnum
|rsid=735665
|Chromosome=11
|position=123490689
|Orientation=plus
|GMAF=0.1074
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=GRAMD1B
|Gene_s=GRAMD1B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.4 | 25.7 | 69.9
| HCB | 0.0 | 1.5 | 98.5
| JPT | 0.0 | 0.9 | 99.1
| YRI | 0.0 | 2.7 | 97.3
| ASW | 0.0 | 3.6 | 96.4
| CHB | 0.0 | 1.5 | 98.5
| CHD | 0.0 | 1.9 | 98.1
| GIH | 2.0 | 18.8 | 79.2
| LWK | 0.0 | 4.5 | 95.5
| MEX | 6.9 | 39.7 | 53.4
| MKK | 0.0 | 1.9 | 98.1
| TSI | 3.9 | 27.5 | 68.6
| HapMapRevision=28
}}[http://blog.23andme.com/2008/08/31/snpwatch-researchers-find-first-snps-linked-to-common-type-of-leukemia/ 23andMe blog] chronic lymphocytic [[leukemia]]
*[[rs735665]] 	A 	1.45

[http://www.newswise.com/articles/view/551128/ news] Slager and colleagues validated these in an independent sample of patients. The strongest association was for [[rs735665]] on 11q24, where the risk was 50 percent higher. This was closely followed by a 39 percent increased risk associated with [[rs9378805]] on 6p25. 

{{GWAS Summary
|SNP=rs735665
|PubMedID=18758461
|Condition=Chronic lymphocytic leukemia
|Gene=GRAMD1B
|Risk Allele=A
|pValue=4.00E-012
|OR=1.45
|95CI=1.31-1.61
}}

{{omim
|desc=LEUKEMIA, CHRONIC LYMPHOCYTIC SUSCEPTIBILITY TO, 5
|id=612559
|rsnum=735665
}}

{{PharmGKB
|RSID=rs735665
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18758461; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia (Initial Sample Size: 505 cases, 1,438 controls; Replication Sample Size: 1,024 cases, 1,677 controls; Risk Allele: rs735665-A). This variant is associated with Chronic lymphocytic leukemia.
|Drugs=
|Drug Classes=
|Diseases=Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356377
}}

{{PMID Auto
|PMID=20332261
|Title=Genetic Susceptibility Variants for Chronic Lymphocytic Leukemia
|OA=1
}}
{{PMID Auto GWAS
|PMID=20639881
|Trait=Follicular lymphoma
|Title=Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
|RiskAllele=T
|Pval=4E-9
|OR=1.81
|ORtxt=[1.50-2.20]
|OA=1
}}

{{PMID Auto
|PMID=20855867
|Title=Inherited genetic susceptibility to monoclonal B-cell lymphocytosis
}}

{{PMID|19620980|OA=1
}} Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

{{PMID|20731705|OA=1
}} Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.

{{PMID Auto GWAS
|PMID=22700719
|Trait=None
|Title=Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
|RiskAllele=A
|Pval=3E-12
|OR=1.5200
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs735665
|overall_frequency_n=11
|overall_frequency_d=128
|overall_frequency=0.0859375
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=11
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23770605
  |Trait=Chronic lymphocytic leukemia
  |Title=Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
  |RiskAllele=A
  |Pval=4E-39
  |OR=1.62
  |ORtxt=[NR]
  |OA=1
}}

{{PMID Auto
|PMID=23455380
|Title=Risk of genome-wide association study-identified genetic variants for non-Hodgkin lymphoma in a Chinese population.
}}

{{PMID Auto GWAS
  |PMID=24292274
  |Trait=Chronic lymphocytic leukemia
  |Title=A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
  |RiskAllele=A
  |Pval=4E-24
  |OR=1.64
  |ORtxt=[NR]
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}